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PCOLCE2 procollagen C-endopeptidase enhancer 2 [ Homo sapiens (human) ]

Gene ID: 26577, updated on 1-Jun-2020

Summary

Official Symbol
PCOLCE2provided by HGNC
Official Full Name
procollagen C-endopeptidase enhancer 2provided by HGNC
Primary source
HGNC:HGNC:8739
See related
Ensembl:ENSG00000163710 MIM:607064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCPE2
Expression
Biased expression in fat (RPKM 75.7), heart (RPKM 31.8) and 9 other tissues See more
Orthologs

Genomic context

See PCOLCE2 in Genome Data Viewer
Location:
3q23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (142817874..142889083, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142536702..142608045, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene plastin 1 Neighboring gene RN7SK pseudogene 25 Neighboring gene transient receptor potential cation channel subfamily C member 1 Neighboring gene RNA, U7 small nuclear 47 pseudogene Neighboring gene ribosomal protein L8 pseudogene 3 Neighboring gene uncharacterized LOC100507389 Neighboring gene progestin and adipoQ receptor family member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
procollagen C-endopeptidase enhancer 2
Names
procollagen C-proteinase enhancer 2
procollagen COOH-terminal proteinase enhancer 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013363.4NP_037495.1  procollagen C-endopeptidase enhancer 2 precursor

    See identical proteins and their annotated locations for NP_037495.1

    Status: VALIDATED

    Source sequence(s)
    AY358557
    Consensus CDS
    CCDS3127.1
    UniProtKB/Swiss-Prot
    Q9UKZ9
    Related
    ENSP00000295992.3, ENST00000295992.8
    Conserved Domains (2) summary
    cd00041
    Location:33143
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:292415
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    142817874..142889083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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