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SRPK3 SRSF protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 26576, updated on 1-Jun-2020

Summary

Official Symbol
SRPK3provided by HGNC
Official Full Name
SRSF protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:11402
See related
Ensembl:ENSG00000184343 MIM:301002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSSK1; STK23; MSSK-1
Summary
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues See more
Orthologs

Genomic context

See SRPK3 in Genome Data Viewer
Location:
Xq28
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153781001..153785732)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153046456..153051187)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily D member 1 Neighboring gene uncharacterized LOC102723591 Neighboring gene plexin B3 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene CRISPRi-validated cis-regulatory element chrX.2654 Neighboring gene signal sequence receptor subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SRSF protein kinase 3 (SRPK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PLXNB3

Homology

Clone Names

  • MGC102944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SRSF protein kinase 3
Names
SFRS protein kinase 3
SR-protein-specific kinase 3
muscle-specific serine kinase 1
serine arginine rich protein-specific kinase 3
serine/threonine kinase 23
serine/threonine-protein kinase 23
serine/threonine-protein kinase SRPK3
NP_001164231.1
NP_001164232.1
NP_055185.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016329.1 RefSeqGene

    Range
    5041..9730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170760.2NP_001164231.1  SRSF protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001164231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    BC117124, U52111
    Consensus CDS
    CCDS55538.1
    UniProtKB/Swiss-Prot
    Q9UPE1
    Related
    ENSP00000359122.1, ENST00000370104.5
    Conserved Domains (1) summary
    cd14218
    Location:68564
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3
  2. NM_001170761.1NP_001164232.1  SRSF protein kinase 3 isoform 3

    See identical proteins and their annotated locations for NP_001164232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AF027406, U52111
    Consensus CDS
    CCDS55537.1
    UniProtKB/Swiss-Prot
    Q9UPE1
    Related
    ENSP00000377376.3, ENST00000393786.7
    Conserved Domains (2) summary
    smart00220
    Location:79531
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:68531
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3
  3. NM_014370.4NP_055185.2  SRSF protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_055185.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC092416, U52111
    Consensus CDS
    CCDS35441.1
    UniProtKB/Swiss-Prot
    Q9UPE1
    Related
    ENSP00000359119.3, ENST00000370101.8
    Conserved Domains (2) summary
    smart00220
    Location:79565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:68565
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153781001..153785732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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