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Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 26569, updated on 5-Jan-2022

Summary

Official Symbol
Slc27a4provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 4provided by MGI
Primary source
MGI:MGI:1347347
See related
Ensembl:ENSMUSG00000059316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FATP4; ACSVL4; BB144259
Summary
Enables oleoyl-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Acts upstream of or within fatty acid metabolic process; lipid transport; and skin development. Located in brush border membrane; endoplasmic reticulum; and microvillus. Is expressed in several structures, including alimentary system; eye; liver; nervous system; and urinary system. Used to study lethal restrictive dermopathy. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in duodenum adult (RPKM 297.3), small intestine adult (RPKM 226.2) and 14 other tissues See more
Orthologs
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Genomic context

See Slc27a4 in Genome Data Viewer
Location:
2 B; 2 20.64 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29692646..29707534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29802634..29817522)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (29658200..29673042)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TruB pseudouridine (psi) synthase family member 2 Neighboring gene coenzyme Q4 Neighboring gene predicted gene, 52595 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene predicted gene, 54109 Neighboring gene microRNA 219b Neighboring gene cerebral endothelial cell adhesion molecule

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oleoyl-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oleoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oleoyl-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import in response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within medium-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within medium-chain fatty acid transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within very long-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
long-chain fatty acid transport protein 4
Names
arachidonate--CoA ligase
long-chain-fatty-acid--CoA ligase
very long-chain acyl-CoA synthetase 4
NP_036119.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011989.5NP_036119.1  long-chain fatty acid transport protein 4

    See identical proteins and their annotated locations for NP_036119.1

    Status: VALIDATED

    Source sequence(s)
    AL845323, BX294378
    Consensus CDS
    CCDS15858.1
    UniProtKB/Swiss-Prot
    Q91VE0
    Related
    ENSMUSP00000078971.3, ENSMUST00000080065.3
    Conserved Domains (2) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:75643
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29692646..29707534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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