Hunk hormonally upregulated Neu-associated kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hunkprovided by MGI
Official Full Name: hormonally upregulated Neu-associated kinaseprovided by MGI
Primary source: MGI:MGI:1347352
See related: Ensembl:ENSMUSG00000053414 AllianceGenome:MGI:1347352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bstk1; Mak-v
Summary: Enables protein kinase activity. Acts upstream of or within protein phosphorylation. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 6.3), CNS E11.5 (RPKM 6.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 51.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (90182550..90296443)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (90385284..90499555)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hunk has a role in normal intestinal proliferation and homeostasis and, although it does not alter overall survival rates, activity of this kinase does impact on tumour initiation rates during the early stages in tumourigenesis in the small intestine.
Title: Hunk/Mak-v is a negative regulator of intestinal cell proliferation.
Hunk is a previously unrecognized link between the Akt and c-myc oncogenic pathway induced by loss of Pten
Title: Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten.
Hunk is required for HER2/neu-induced mammary tumorigenesis
Title: Hunk is required for HER2/neu-induced mammary tumorigenesis.
Data show that HUNK reconstitution in basal breast cancer cell lines prevented protein phosphatase 2-A (PP2A from binding to CFL-1.
Title: HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
Reconstitution experiments revealed that Hunk is sufficient to restore the metastatic potential of Hunk-deficient mammary tumor cells, as well as defects in migration and invasion, and does so in a manner that requires its kinase activity.
Title: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.
The region between nt -508 and -347 of mak-v/Hunk promoter region has a pronounced stimulating effect on transcription activity.
Title: [Molecular cloning and characterization of the mouse mak-v/Hunk gene promoter].
Could have role in both developmental and physiological functioning of distal nephron via modulation of cellular proliferation.
Title: Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hunk (e-PCR), detects polymorphism
- UniSTS:259089

Hunk (e-PCR), detects polymorphism
- UniSTS:259619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hormonally up-regulated neu tumor-associated kinase

Names: serine/threonine-protein kinase MAK-V

NP_056570.1

EC 2.7.11.1

XP_011244432.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015755.2 → NP_056570.1 hormonally up-regulated neu tumor-associated kinase

See identical proteins and their annotated locations for NP_056570.1

Status: PROVISIONAL

Source sequence(s)

AC131339, AC133505

Consensus CDS

CCDS28315.1

UniProtKB/Swiss-Prot

O88866

UniProtKB/TrEMBL

B2RQ72

Related

ENSMUSP00000068007.7, ENSMUST00000065856.8

Conserved Domains (2) summary

smart00220
Location:61 → 320

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14070
Location:58 → 320

STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

90182550..90296443

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246130.3 → XP_011244432.1 hormonally up-regulated neu tumor-associated kinase isoform X1

UniProtKB/TrEMBL

Q3UGV4

Conserved Domains (1) summary

cl21453
Location:13 → 261

PKc_like; Protein Kinases, catalytic domain