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Homer3 homer scaffolding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 26558, updated on 9-Apr-2019

Summary

Official Symbol
Homer3provided by MGI
Official Full Name
homer scaffolding protein 3provided by MGI
Primary source
MGI:MGI:1347359
See related
Ensembl:ENSMUSG00000003573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW146114
Expression
Ubiquitous expression in cerebellum adult (RPKM 62.8), ovary adult (RPKM 38.6) and 27 other tissues See more
Orthologs

Genomic context

See Homer3 in Genome Data Viewer
Location:
8; 8 B3.3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70282891..70294361)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72806898..72818260)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 6 Neighboring gene SURP and G patch domain containing 2 Neighboring gene predicted gene, 38427 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 regulator of nonsense transcripts homolog (yeast)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
basal part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homer protein homolog 3
Names
homer homolog 3
homer, neuronal immediate early gene, 3
homer-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146153.1NP_001139625.1  homer protein homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001139625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158553, BU054773, CX208892
    Consensus CDS
    CCDS52569.1
    UniProtKB/Swiss-Prot
    Q99JP6
    Related
    ENSMUSP00000105751.2, ENSMUST00000110124.8
    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
  2. NM_011984.2NP_036114.2  homer protein homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_036114.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC158553, BU054773, CX208892
    Consensus CDS
    CCDS22363.1
    UniProtKB/Swiss-Prot
    Q99JP6
    Related
    ENSMUSP00000117033.1, ENSMUST00000140212.7
    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    70282891..70294361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509681.2XP_006509744.1  homer protein homolog 3 isoform X2

    Conserved Domains (1) summary
    cl17171
    Location:56114
    PH-like; Pleckstrin homology-like domain
  2. XM_006509679.1XP_006509742.1  homer protein homolog 3 isoform X1

    See identical proteins and their annotated locations for XP_006509742.1

    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
  3. XM_006509680.3XP_006509743.1  homer protein homolog 3 isoform X1

    See identical proteins and their annotated locations for XP_006509743.1

    Conserved Domains (1) summary
    cd01206
    Location:6114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
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