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Homer2 homer scaffolding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26557, updated on 8-Feb-2024

Summary

Official Symbol
Homer2provided by MGI
Official Full Name
homer scaffolding protein 2provided by MGI
Primary source
MGI:MGI:1347354
See related
Ensembl:ENSMUSG00000025813 AllianceGenome:MGI:1347354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPD; Vesl-2; 9330120H11Rik
Summary
Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; and chemical homeostasis within a tissue. Located in several cellular components, including apical part of cell; postsynaptic density; and stereocilium tip. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 4.6) and 20 other tissues See more
Orthologs
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Genomic context

See Homer2 in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81250229..81356673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81600481..81706925, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_19369 Neighboring gene STARR-positive B cell enhancer mm9_chr7:88715937-88716238 Neighboring gene WAS protein homolog associated with actin, golgi membranes and microtubules Neighboring gene microRNA 12203 Neighboring gene predicted gene, 32579 Neighboring gene predicted gene, 42400

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables synaptic receptor adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homer protein homolog 2
Names
VASP/Ena-related gene up-regulated during seizure and LTP 2
cupidin
homer homolog 2
homer, neuronal immediate early gene, 2
homer-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164086.1NP_001157558.1  homer protein homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001157558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC140366, AF093259, AK163423
    Consensus CDS
    CCDS85329.1
    UniProtKB/Swiss-Prot
    Q9QWW1
    Related
    ENSMUSP00000026922.9, ENSMUST00000026922.15
    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02169
    Location:100315
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. NM_001164087.1NP_001157559.1  homer protein homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001157559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140366, AF093260, CJ083069, DV657327
    Consensus CDS
    CCDS52284.1
    UniProtKB/TrEMBL
    E9Q4F9
    Related
    ENSMUSP00000095931.3, ENSMUST00000098326.3
    Conserved Domains (2) summary
    TIGR02168
    Location:103278
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:147
    PH-like; Pleckstrin homology-like domain
  3. NM_011983.2NP_036113.1  homer protein homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_036113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC140366, AF093260, AK163423
    Consensus CDS
    CCDS40009.1
    UniProtKB/Swiss-Prot
    O89025, Q9QWW1, Q9Z0E4
    Related
    ENSMUSP00000146787.2, ENSMUST00000207983.2
    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:167342
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81250229..81356673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540909.1XP_006540972.1  homer protein homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006540972.1

    UniProtKB/TrEMBL
    E9Q4F9
    Conserved Domains (2) summary
    TIGR02168
    Location:103278
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:147
    PH-like; Pleckstrin homology-like domain
  2. XM_030242611.2XP_030098471.1  homer protein homolog 2 isoform X2

    Conserved Domains (2) summary
    TIGR02169
    Location:36251
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl17171
    Location:147
    PH-like; Pleckstrin homology-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177029.3: Suppressed sequence

    Description
    NM_177029.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.