PF3D7_0709000 chloroquine resistance transporter [Plasmodium falciparum 3D7] - Gene

Summary

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Gene symbol: PF3D7_0709000
Gene description: chloroquine resistance transporter
Locus tag: PF3D7_0709000
See related: PlasmoDB:PF3D7_0709000; VEuPathDB:PF3D7_0709000
Gene type: protein coding
RNA name: chloroquine resistance transporter
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs: all
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Genomic context

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See PF3D7_0709000 in Genome Data Viewer

Location:: chromosome: 7

Exon count:: 13

Sequence:: Chromosome: 7; NC_004328.3 (403222..406317)

Chromosome 7 - NC_004328.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_004328.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.
Title: A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.
PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.
Title: PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.
Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.
Title: Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.
Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
Title: Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
Title: Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
Title: Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates.
Title: Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates.
Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
Title: Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
The natural function of the malaria parasite's chloroquine resistance transporter.
Title: The natural function of the malaria parasite's chloroquine resistance transporter.
structure, at 3.2 A resolution, of the PfCRT isoform of CQ-resistant, PPQ-sensitive South American 7G8 parasites, using single-particle cryo-electron microscopy and antigen-binding fragment technology
Title: Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B5M47 (e-PCR)
- UniSTS:105285

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by GeneDB

Function	Evidence Code	Pubs
enables ferric iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glutathione transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in food vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed