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OR10H3 olfactory receptor family 10 subfamily H member 3 [ Homo sapiens (human) ]

Gene ID: 26532, updated on 11-Jun-2021

Summary

Official Symbol
OR10H3provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily H member 3provided by HGNC
Primary source
HGNC:HGNC:8174
See related
Ensembl:ENSG00000171936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR10H3 in Genome Data Viewer
Location:
19p13.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15737985..15742343)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15848795..15853153)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 12 Neighboring gene olfactory receptor family 10 subfamily H member 2 Neighboring gene cytochrome P450 family 4 subfamily F member 24, pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 5

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of olfactory receptor, family 10, subfamily H, member 3 (OR10H3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119147, MGC119149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 10H3
Names
olfactory receptor OR19-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013938.2NP_039226.1  olfactory receptor 10H3

    See identical proteins and their annotated locations for NP_039226.1

    Status: VALIDATED

    Source sequence(s)
    AC004597, AC104533
    Consensus CDS
    CCDS12334.1
    UniProtKB/Swiss-Prot
    O60404
    UniProtKB/TrEMBL
    A0A126GW93
    Related
    ENSP00000493287.1, ENST00000641646.1
    Conserved Domains (1) summary
    cl21561
    Location:42310
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15737985..15742343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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