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TSPAN16 tetraspanin 16 [ Homo sapiens (human) ]

Gene ID: 26526, updated on 11-Jun-2021

Summary

Official Symbol
TSPAN16provided by HGNC
Official Full Name
tetraspanin 16provided by HGNC
Primary source
HGNC:HGNC:30725
See related
Ensembl:ENSG00000130167 MIM:617580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM-8; TM4-B; TM4SF16
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Expression
Restricted expression toward testis (RPKM 28.9) See more
Orthologs
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Genomic context

See TSPAN16 in Genome Data Viewer
Location:
19p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11296144..11326996)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11406836..11437672)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372273 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8 Neighboring gene uncharacterized HSPC102 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-16
Names
tetraspanin TM4-B
transmembrane 4 superfamily member 16
tspan-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282509.2NP_001269438.1  tetraspanin-16 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI688554, AW169944, BM560276, DB457828
    Consensus CDS
    CCDS62549.1
    UniProtKB/Swiss-Prot
    Q9UKR8
    Related
    ENSP00000467341.1, ENST00000590327.6
    Conserved Domains (2) summary
    cd03156
    Location:120215
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:19240
    Tetraspannin; Tetraspanin family
  2. NM_001282510.2NP_001269439.1  tetraspanin-16 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AI688554, AW169944, BM560276, DB457828
    Consensus CDS
    CCDS62550.1
    UniProtKB/Swiss-Prot
    Q9UKR8
    Related
    ENSP00000466751.1, ENST00000592955.5
    Conserved Domains (2) summary
    cd03156
    Location:95190
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:19215
    Tetraspannin; Tetraspanin family
  3. NM_012466.4NP_036598.1  tetraspanin-16 isoform 1

    See identical proteins and their annotated locations for NP_036598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF133424, DB457828
    Consensus CDS
    CCDS12256.1
    UniProtKB/Swiss-Prot
    Q9UKR8
    Related
    ENSP00000319486.1, ENST00000316737.5
    Conserved Domains (2) summary
    cd03156
    Location:120215
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:19232
    Tetraspannin; Tetraspanin family

RNA

  1. NR_104199.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' end and uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI688554, AW169944, BC029908, DB457828
    Related
    ENST00000337994.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11296144..11326996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527901.1XP_011526203.1  tetraspanin-16 isoform X1

    Conserved Domains (2) summary
    cd03156
    Location:120201
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:19201
    Tetraspannin; Tetraspanin family
  2. XM_011527902.1XP_011526204.1  tetraspanin-16 isoform X2

    Conserved Domains (2) summary
    cl02781
    Location:115179
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:19204
    Tetraspannin; Tetraspanin family
  3. XM_024451450.1XP_024307218.1  tetraspanin-16 isoform X3

    Conserved Domains (1) summary
    cd03156
    Location:95176
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  4. XM_011527903.3XP_011526205.1  tetraspanin-16 isoform X4

    Conserved Domains (2) summary
    cd03156
    Location:57152
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1177
    Tetraspannin; Tetraspanin family
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