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LATS2 large tumor suppressor kinase 2 [ Homo sapiens (human) ]

Gene ID: 26524, updated on 10-Oct-2019

Summary

Official Symbol
LATS2provided by HGNC
Official Full Name
large tumor suppressor kinase 2provided by HGNC
Primary source
HGNC:HGNC:6515
See related
Ensembl:ENSG00000150457 MIM:604861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KPM
Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See LATS2 in Genome Data Viewer
Location:
13q12.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (20973036..21061586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21547175..21635722, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 27 Neighboring gene ribosomal protein SA pseudogene 54 Neighboring gene RNA, U4 small nuclear 9, pseudogene Neighboring gene uncharacterized LOC105370104 Neighboring gene ribosomal protein S12 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Coregulation of Androgen receptor activity, organism-specific biosystem
    Coregulation of Androgen receptor activity
  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase LATS2
Names
LATS (large tumor suppressor, Drosophila) homolog 2
LATS, large tumor suppressor, homolog 2
kinase phosphorylated during mitosis protein
large tumor suppressor homolog 2
serine/threonine kinase KPM
serine/threonine-protein kinase kpm
warts-like kinase
NP_055387.2
XP_005266399.1
XP_011533344.1
XP_016876030.1
XP_016876031.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014572.3NP_055387.2  serine/threonine-protein kinase LATS2

    See identical proteins and their annotated locations for NP_055387.2

    Status: REVIEWED

    Source sequence(s)
    AF207547, AL161613, AL356285, BQ774580, DB452765
    Consensus CDS
    CCDS9294.1
    UniProtKB/Swiss-Prot
    Q9NRM7
    UniProtKB/TrEMBL
    A0A024RDM3
    Related
    ENSP00000372035.4, ENST00000382592.5
    Conserved Domains (3) summary
    cd05626
    Location:6661046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    20973036..21061586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020542.1XP_016876031.1  serine/threonine-protein kinase LATS2 isoform X4

  2. XM_005266342.1XP_005266399.1  serine/threonine-protein kinase LATS2 isoform X1

    See identical proteins and their annotated locations for XP_005266399.1

    UniProtKB/Swiss-Prot
    Q9NRM7
    UniProtKB/TrEMBL
    A0A024RDM3
    Conserved Domains (3) summary
    cd05626
    Location:6661046
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:668973
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:101141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
  3. XM_017020541.1XP_016876030.1  serine/threonine-protein kinase LATS2 isoform X3

  4. XM_011535042.2XP_011533344.1  serine/threonine-protein kinase LATS2 isoform X2

    Conserved Domains (3) summary
    cd05626
    Location:579959
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    smart00220
    Location:581886
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21463
    Location:2454
    UBA_like_SF; UBA domain-like superfamily
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