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TIMM9 translocase of inner mitochondrial membrane 9 [ Homo sapiens (human) ]

Gene ID: 26520, updated on 12-Jan-2019

Summary

Official Symbol
TIMM9provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 9provided by HGNC
Primary source
HGNC:HGNC:11819
See related
Ensembl:ENSG00000100575 MIM:607384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM9; TIM9A
Summary
TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in thyroid (RPKM 11.9), ovary (RPKM 11.7) and 25 other tissues See more
Orthologs

Genomic context

See TIMM9 in Genome Data Viewer
Location:
14q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (58408494..58427614, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58875370..58894232, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene PSMA3 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 341, pseudogene Neighboring gene AT-rich interaction domain 4A Neighboring gene uncharacterized LOC105370522 Neighboring gene translocase of outer mitochondrial membrane 20 like Neighboring gene KIAA0586 Neighboring gene heat shock factor binding protein 1 pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemA human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four lo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein transport IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
 
sensory perception of sound TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim9
Names
translocase of inner mitochondrial membrane 9 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304485.1NP_001291414.1  mitochondrial import inner membrane translocase subunit Tim9 isoform a

    See identical proteins and their annotated locations for NP_001291414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    AA889245, AL139021, BC020213, BF034731, DA530575
    Consensus CDS
    CCDS9735.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A024R648
    Conserved Domains (1) summary
    pfam02953
    Location:1067
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  2. NM_001304486.1NP_001291415.1  mitochondrial import inner membrane translocase subunit Tim9 isoform a

    See identical proteins and their annotated locations for NP_001291415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    AA889245, AK312095, AL139021, BC020213
    Consensus CDS
    CCDS9735.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A024R648
    Related
    ENSP00000451198.1, ENST00000555404.5
    Conserved Domains (1) summary
    pfam02953
    Location:1067
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  3. NM_001304487.1NP_001291416.1  mitochondrial import inner membrane translocase subunit Tim9 isoform a

    See identical proteins and their annotated locations for NP_001291416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    AL139021, BC054875, DA530575
    Consensus CDS
    CCDS9735.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A024R648
    Related
    ENSP00000451006.1, ENST00000555593.5
    Conserved Domains (1) summary
    pfam02953
    Location:1067
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  4. NM_001304488.1NP_001291417.1  mitochondrial import inner membrane translocase subunit Tim9 isoform b

    See identical proteins and their annotated locations for NP_001291417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA889245, AL139021, BC020213, BG249379
    Consensus CDS
    CCDS76685.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    G3V502
    Related
    ENSP00000452091.1, ENST00000556007.6
    Conserved Domains (1) summary
    pfam02953
    Location:1046
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  5. NM_001304489.1NP_001291418.1  mitochondrial import inner membrane translocase subunit Tim9 isoform c

    See identical proteins and their annotated locations for NP_001291418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AA889245, AL139021, BC020213, W74224
    Consensus CDS
    CCDS86394.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A1W2PQS5
    Related
    ENSP00000492122.1, ENST00000555930.6
    Conserved Domains (1) summary
    pfam02953
    Location:1047
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  6. NM_001304490.1NP_001291419.1  mitochondrial import inner membrane translocase subunit Tim9 isoform d

    See identical proteins and their annotated locations for NP_001291419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Variants 7 and 8 encode the same isoform.
    Source sequence(s)
    AA889245, AL139021, BC020213, DN912572
    Consensus CDS
    CCDS86393.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A1W2PRH9
    Related
    ENSP00000492665.1, ENST00000556367.6
    Conserved Domains (1) summary
    pfam02953
    Location:1046
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  7. NM_001304491.1NP_001291420.1  mitochondrial import inner membrane translocase subunit Tim9 isoform d

    See identical proteins and their annotated locations for NP_001291420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5'UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Variants 7 and 8 encode the same isoform.
    Source sequence(s)
    AA889245, AL139021, BC020213, HY041857
    Consensus CDS
    CCDS86393.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A1W2PRH9
    Conserved Domains (1) summary
    pfam02953
    Location:1046
    zf-Tim10_DDP; Tim10/DDP family zinc finger
  8. NM_012460.4NP_036592.1  mitochondrial import inner membrane translocase subunit Tim9 isoform a

    See identical proteins and their annotated locations for NP_036592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 through 4 encode the same isoform.
    Source sequence(s)
    AL139021, BC020213, DA530575
    Consensus CDS
    CCDS9735.1
    UniProtKB/Swiss-Prot
    Q9Y5J7
    UniProtKB/TrEMBL
    A0A024R648
    Related
    ENSP00000378588.2, ENST00000395159.6
    Conserved Domains (1) summary
    pfam02953
    Location:1067
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RNA

  1. NR_130750.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA889245, AL139021, BC020213, BM811095, DA530575
    Related
    ENST00000216463.8
  2. NR_130751.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an alternate internal exon, and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA889245, AL139021, BC020213, HY096567
  3. NR_130752.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA889245, AL139021, BC020213, DB110327
  4. NR_130753.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA889245, AL139021, BC020213, HY139570

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    58408494..58427614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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