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TIMM10 translocase of inner mitochondrial membrane 10 [ Homo sapiens (human) ]

Gene ID: 26519, updated on 8-Jul-2018
Official Symbol
TIMM10provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 10provided by HGNC
Primary source
HGNC:HGNC:11814
See related
Ensembl:ENSG00000134809 MIM:602251; Vega:OTTHUMG00000167039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM10; TIM10A; TIMM10A
Summary
The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues See more
Orthologs
See TIMM10 in Genome Data Viewer
Location:
11q12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (57528463..57542505, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57295936..57298232, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 43 member 1 Neighboring gene RNA, 7SL, cytoplasmic 605, pseudogene Neighboring gene smoothelin like 1 Neighboring gene ubiquitin conjugating enzyme E2 L6 Neighboring gene ribosomal protein S4X pseudogene 13

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human translocase of inner mitochondrial membrane 10 homolog (yeast) (TIMM10) at amino acid residues 72-73 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemA human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four lo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein transport IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
sensory perception of sound TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial inner membrane presequence translocase complex TAS
Traceable Author Statement
more info
PubMed 
mitochondrial inner membrane protein insertion complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrial intermembrane space TAS
Traceable Author Statement
more info
PubMed 
mitochondrial intermembrane space protein transporter complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
mitochondrial import inner membrane translocase subunit Tim10
Names
translocase of inner mitochondrial membrane 10 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012456.2NP_036588.1  mitochondrial import inner membrane translocase subunit Tim10

    See identical proteins and their annotated locations for NP_036588.1

    Status: REVIEWED

    Source sequence(s)
    AF150089, AI498204, CB106298
    Consensus CDS
    CCDS7959.1
    UniProtKB/Swiss-Prot
    P62072
    Related
    ENSP00000257245.4, OTTHUMP00000234850, ENST00000257245.8, OTTHUMT00000392595
    Conserved Domains (1) summary
    pfam02953
    Location:769
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    57528463..57542505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448436.1XP_024304204.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    Conserved Domains (1) summary
    pfam02953
    Location:769
    zf-Tim10_DDP; Tim10/DDP family zinc finger
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