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TIMM10B translocase of inner mitochondrial membrane 10B [ Homo sapiens (human) ]

Gene ID: 26515, updated on 18-Aug-2020

Summary

Official Symbol
TIMM10Bprovided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 10Bprovided by HGNC
Primary source
HGNC:HGNC:4022
See related
Ensembl:ENSG00000132286 MIM:607388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FXC1; Tim9b; TIM10B
Summary
FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in thyroid (RPKM 18.0), prostate (RPKM 12.0) and 25 other tissues See more
Orthologs

Genomic context

See TIMM10B in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6481501..6484681)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6502677..6506109)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene ADP ribosylation factor interacting protein 2 Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DNHD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim10 B
Names
fracture callus 1 homolog
fracture callus protein 1
mitochondrial import inner membrane translocase subunit Tim9 B
translocase of inner mitochondrial membrane 10 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012192.4NP_036324.1  mitochondrial import inner membrane translocase subunit Tim10 B

    See identical proteins and their annotated locations for NP_036324.1

    Status: VALIDATED

    Source sequence(s)
    AC084337, AI052126, BC011014, DA290694
    Consensus CDS
    CCDS7766.1
    UniProtKB/Swiss-Prot
    Q9Y5J6
    UniProtKB/TrEMBL
    B2R4A9
    Related
    ENSP00000254616.6, ENST00000254616.11
    Conserved Domains (1) summary
    pfam02953
    Location:1267
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6481501..6484681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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