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NUPR1 nuclear protein 1, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 26471, updated on 19-Sep-2021

Summary

Official Symbol
NUPR1provided by HGNC
Official Full Name
nuclear protein 1, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:29990
See related
Ensembl:ENSG00000176046 MIM:614812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P8; COM1
Expression
Broad expression in thyroid (RPKM 197.1), pancreas (RPKM 192.3) and 21 other tissues See more
Orthologs
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Genomic context

See NUPR1 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28532708..28538974, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28544029..28550295, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene apolipoprotein B receptor Neighboring gene interleukin 27 Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene sulfotransferase family 1A member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Common variants at five new loci associated with early-onset inflammatory bowel disease.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyltransferase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in protein acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of female gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear protein 1
Names
candidate of metastasis 1
nuclear protein, transcriptional regulator, 1
nuclear transcriptional regulator protein 1
protein p8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042483.2NP_001035948.1  nuclear protein 1 isoform a

    See identical proteins and their annotated locations for NP_001035948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC020765, AF069073, BF965595, BP214401
    Consensus CDS
    CCDS42137.1
    UniProtKB/Swiss-Prot
    O60356
    Related
    ENSP00000379003.2, ENST00000395641.2
    Conserved Domains (1) summary
    pfam10195
    Location:6794
    Phospho_p8; DNA-binding nuclear phosphoprotein p8
  2. NM_012385.3NP_036517.1  nuclear protein 1 isoform b

    See identical proteins and their annotated locations for NP_036517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC020765, AF069073
    Consensus CDS
    CCDS10634.1
    UniProtKB/Swiss-Prot
    O60356
    UniProtKB/TrEMBL
    A0A024QZC4
    Related
    ENSP00000315559.7, ENST00000324873.8
    Conserved Domains (1) summary
    pfam10195
    Location:2176
    Phospho_p8; DNA-binding nuclear phosphoprotein p8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28532708..28538974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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