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PTPN18 protein tyrosine phosphatase, non-receptor type 18 [ Homo sapiens (human) ]

Gene ID: 26469, updated on 7-Dec-2018

Summary

Official Symbol
PTPN18provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 18provided by HGNC
Primary source
HGNC:HGNC:9649
See related
Ensembl:ENSG00000072135 MIM:606587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDP1; PTP-HSCF
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in lymph node (RPKM 34.1), spleen (RPKM 27.5) and 25 other tissues See more
Orthologs

Genomic context

See PTPN18 in Genome Data Viewer
Location:
2q21.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (130356007..130375409)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131113580..131132982)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (TTC) 1-1 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP4, U3 small nucleolar ribonucleoprotein Neighboring gene uncharacterized LOC105373618 Neighboring gene fatty acyl-CoA reductase 2 pseudogene 2 Neighboring gene Kruppel like factor 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
  • Downregulation of ERBB2 signaling, organism-specific biosystem (from REACTOME)
    Downregulation of ERBB2 signaling, organism-specific biosystemSignaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dep...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
blastocyst formation IEA
Inferred from Electronic Annotation
more info
 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
negative regulation of ERBB signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 18
Names
brain-derived phosphatase
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
NP_001135842.1
NP_055184.2
XP_006712479.1
XP_006712480.1
XP_016859287.1
XP_024308557.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142370.1NP_001135842.1  tyrosine-protein phosphatase non-receptor type 18 isoform 2

    See identical proteins and their annotated locations for NP_001135842.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks four internal exons in the 5' coding region that results in the loss of an in-frame segment, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC132479, AK303804, BM789073, CA310199, DN995571
    Consensus CDS
    CCDS46410.1
    UniProtKB/Swiss-Prot
    Q99952
    Related
    ENSP00000310092.5, ENST00000347849.7
    Conserved Domains (2) summary
    cd00047
    Location:32183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:32183
    Y_phosphatase; Protein-tyrosine phosphatase
  2. NM_014369.4NP_055184.2  tyrosine-protein phosphatase non-receptor type 18 isoform 1

    See identical proteins and their annotated locations for NP_055184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132479, AK303804, BM789073, CA310199, DN995571, X79568
    Consensus CDS
    CCDS2161.1
    UniProtKB/Swiss-Prot
    Q99952
    Related
    ENSP00000175756.5, ENST00000175756.9
    Conserved Domains (2) summary
    cd00047
    Location:59290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:56290
    Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    130356007..130375409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712417.1XP_006712480.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

    See identical proteins and their annotated locations for XP_006712480.1

    Conserved Domains (2) summary
    cd00047
    Location:59290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:56290
    Y_phosphatase; Protein-tyrosine phosphatase
  2. XM_024452789.1XP_024308557.1  tyrosine-protein phosphatase non-receptor type 18 isoform X2

    Conserved Domains (1) summary
    cd00047
    Location:59290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_006712416.4XP_006712479.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

    Conserved Domains (2) summary
    cd00047
    Location:32183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:32183
    Y_phosphatase; Protein-tyrosine phosphatase
  4. XM_017003798.1XP_016859287.1  tyrosine-protein phosphatase non-receptor type 18 isoform X4

    Related
    ENSP00000387031.2, ENST00000409022.2
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