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Psmb2 proteasome (prosome, macropain) subunit, beta type 2 [ Mus musculus (house mouse) ]

Gene ID: 26445, updated on 1-Mar-2024

Summary

Official Symbol
Psmb2provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 2provided by MGI
Primary source
MGI:MGI:1347045
See related
Ensembl:ENSMUSG00000028837 AllianceGenome:MGI:1347045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C7-I; HC7-I; D4Wsu33e
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteasomal protein catabolic process. Part of proteasome core complex. Is expressed in embryo; extraembryonic component; and nucleus pulposus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 90.9), placenta adult (RPKM 89.8) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb2 in Genome Data Viewer
Location:
4 D2.2; 4 60.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126571460..126603503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126677637..126709715)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46870 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:126354636-126354937 Neighboring gene transcription factor AP-2, epsilon Neighboring gene STARR-positive B cell enhancer mm9_chr4:126430552-126430853 Neighboring gene neurochondrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proteasome subunit beta type-2
Names
macropain subunit C7-I
multicatalytic endopeptidase complex subunit C7-I
proteasome component C7-I
NP_001411865.1
NP_036100.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424936.1NP_001411865.1  proteasome subunit beta type-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607129
  2. NM_011970.5NP_036100.3  proteasome subunit beta type-2 isoform 1

    See identical proteins and their annotated locations for NP_036100.3

    Status: VALIDATED

    Source sequence(s)
    AL607129
    Consensus CDS
    CCDS18657.1
    UniProtKB/Swiss-Prot
    Q9R1P3
    UniProtKB/TrEMBL
    Q8BJX0
    Related
    ENSMUSP00000030642.3, ENSMUST00000030642.3
    Conserved Domains (1) summary
    cd03758
    Location:1192
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126571460..126603503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)