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Psma7 proteasome subunit alpha 7 [ Mus musculus (house mouse) ]

Gene ID: 26444, updated on 1-Mar-2024

Summary

Official Symbol
Psma7provided by MGI
Official Full Name
proteasome subunit alpha 7provided by MGI
Primary source
MGI:MGI:1347070
See related
Ensembl:ENSMUSG00000027566 AllianceGenome:MGI:1347070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6-I
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in proteasomal protein catabolic process. Located in postsynapse. Part of proteasome core complex. Is expressed in pancreas epithelium. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 74.2), CNS E14 (RPKM 56.3) and 28 other tissues See more
Orthologs
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Genomic context

See Psma7 in Genome Data Viewer
Location:
2 H4; 2 102.55 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179678160..179684257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180036367..180042464, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene LSM family member 14B Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene mitochondrial ribosome associated GTPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-7
Names
proteasome (prosome, macropain) subunit, alpha type 7
proteasome subunit RC6-1
NP_001276405.1
NP_036099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289476.1NP_001276405.1  proteasome subunit alpha type-7 isoform 2

    See identical proteins and their annotated locations for NP_001276405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK146765, AL663067, BU841938, BY779773, CJ307624, DV049235
    UniProtKB/TrEMBL
    Q3THL2
    Related
    ENSMUST00000126021.8
    Conserved Domains (1) summary
    cl00467
    Location:1141
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_011969.2NP_036099.1  proteasome subunit alpha type-7 isoform 1

    See identical proteins and their annotated locations for NP_036099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK146765, BU841938, BY779773, CJ307624, DV049235
    Consensus CDS
    CCDS17166.1
    UniProtKB/Swiss-Prot
    Q9Z2U0
    UniProtKB/TrEMBL
    Q3TN31, Q3UIT9, Q542H2
    Related
    ENSMUSP00000029082.9, ENSMUST00000029082.9
    Conserved Domains (1) summary
    cd03755
    Location:3211
    proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179678160..179684257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)