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Psma7 proteasome (prosome, macropain) subunit, alpha type 7 [ Mus musculus (house mouse) ]

Gene ID: 26444, updated on 8-Jul-2018
Official Symbol
Psma7provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, alpha type 7provided by MGI
Primary source
MGI:MGI:1347070
See related
Ensembl:ENSMUSG00000027566 Vega:OTTMUSG00000016235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6-I
Expression
Ubiquitous expression in CNS E11.5 (RPKM 74.2), CNS E14 (RPKM 56.3) and 28 other tissues See more
Orthologs
See Psma7 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (180036367..180042464, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (179771081..179777107, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene LSM family member 14B Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene mitochondrial ribosome associated GTPase 2

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proteasome subunit alpha type-7
Names
proteasome subunit RC6-1
NP_001276405.1
NP_036099.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289476.1NP_001276405.1  proteasome subunit alpha type-7 isoform 2

    See identical proteins and their annotated locations for NP_001276405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK146765, AL663067, BU841938, BY779773, CJ307624, DV049235
    UniProtKB/TrEMBL
    Q3THL2, Q3UIT9
    Conserved Domains (1) summary
    cl00467
    Location:1141
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_011969.2NP_036099.1  proteasome subunit alpha type-7 isoform 1

    See identical proteins and their annotated locations for NP_036099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK146765, BU841938, BY779773, CJ307624, DV049235
    Consensus CDS
    CCDS17166.1
    UniProtKB/Swiss-Prot
    Q9Z2U0
    UniProtKB/TrEMBL
    Q3UIT9, Q542H2
    Related
    ENSMUSP00000029082.8, OTTMUSP00000017387, ENSMUST00000029082.8, OTTMUST00000038904
    Conserved Domains (1) summary
    cd03755
    Location:3211
    proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    180036367..180042464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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