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Psma6 proteasome subunit alpha 6 [ Mus musculus (house mouse) ]

Gene ID: 26443, updated on 8-Feb-2024

Summary

Official Symbol
Psma6provided by MGI
Official Full Name
proteasome subunit alpha 6provided by MGI
Primary source
MGI:MGI:1347006
See related
Ensembl:ENSMUSG00000021024 AllianceGenome:MGI:1347006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IOTA
Summary
Enables RNA binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteasomal protein catabolic process. Located in P-body and nuclear matrix. Part of proteasome core complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 121.3), placenta adult (RPKM 65.6) and 24 other tissues See more
Orthologs
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Genomic context

See Psma6 in Genome Data Viewer
Location:
12 C1; 12 23.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55431007..55465244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55384222..55418459)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene STARR-positive B cell enhancer ABC_E3052 Neighboring gene STARR-positive B cell enhancer ABC_E3053 Neighboring gene protein only RNase P catalytic subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56490469-56490652 Neighboring gene STARR-positive B cell enhancer ABC_E8483 Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-6
Names
macropain iota chain
multicatalytic endopeptidase complex iota chain
proteasome (prosome, macropain) subunit, alpha type 6
proteasome iota chain
NP_001297512.1
NP_036098.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310583.1NP_001297512.1  proteasome subunit alpha type-6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159636
    Consensus CDS
    CCDS79114.1
    UniProtKB/TrEMBL
    E0CXB1
    Related
    ENSMUSP00000124781.2, ENSMUST00000163070.8
    Conserved Domains (1) summary
    cd03754
    Location:8201
    proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
  2. NM_011968.3NP_036098.1  proteasome subunit alpha type-6 isoform 1

    See identical proteins and their annotated locations for NP_036098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AV265469, BC086685, BY340104
    Consensus CDS
    CCDS25917.1
    UniProtKB/Swiss-Prot
    Q0VGS3, Q3TT07, Q3U6Y2, Q9QUM9
    Related
    ENSMUSP00000021412.9, ENSMUST00000021412.9
    Conserved Domains (1) summary
    cd03754
    Location:8220
    proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55431007..55465244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)