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Psma6 proteasome (prosome, macropain) subunit, alpha type 6 [ Mus musculus (house mouse) ]

Gene ID: 26443, updated on 8-Jul-2018
Official Symbol
Psma6provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, alpha type 6provided by MGI
Primary source
MGI:MGI:1347006
See related
Ensembl:ENSMUSG00000021024 Vega:OTTMUSG00000034926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IOTA
Expression
Ubiquitous expression in testis adult (RPKM 121.3), placenta adult (RPKM 65.6) and 24 other tissues See more
Orthologs
See Psma6 in Genome Data Viewer
Location:
12; 12 C1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (55384222..55418459)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56499812..56519446)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene RIKEN cDNA 1110008L16 gene Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
myofibril ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
polysome ISO
Inferred from Sequence Orthology
more info
 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
 
sarcomere ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proteasome subunit alpha type-6
Names
macropain iota chain
multicatalytic endopeptidase complex iota chain
proteasome iota chain
NP_001297512.1
NP_036098.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310583.1NP_001297512.1  proteasome subunit alpha type-6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159636
    Consensus CDS
    CCDS79114.1
    UniProtKB/TrEMBL
    E0CXB1
    Related
    ENSMUSP00000124781.1, OTTMUSP00000048452, ENSMUST00000163070.7, OTTMUST00000088809
    Conserved Domains (1) summary
    cd03754
    Location:8201
    proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
  2. NM_011968.3NP_036098.1  proteasome subunit alpha type-6 isoform 1

    See identical proteins and their annotated locations for NP_036098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AV265469, BC086685, BY340104
    Consensus CDS
    CCDS25917.1
    UniProtKB/Swiss-Prot
    Q9QUM9
    Related
    ENSMUSP00000021412.8, OTTMUSP00000048451, ENSMUST00000021412.8, OTTMUST00000088808
    Conserved Domains (1) summary
    cd03754
    Location:8220
    proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    55384222..55418459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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