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Psma1 proteasome subunit alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 26440, updated on 8-Dec-2022

Summary

Official Symbol
Psma1provided by MGI
Official Full Name
proteasome subunit alpha 1provided by MGI
Primary source
MGI:MGI:1347005
See related
Ensembl:ENSMUSG00000030751 AllianceGenome:MGI:1347005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C2; HC2; Pros-30; alpha-type
Summary
Enables lipopolysaccharide binding activity. Involved in negative regulation of inflammatory response to antigenic stimulus. Part of proteasome core complex. Is expressed in several structures, including alimentary system; brain ventricular layer; cranial ganglion; musculoskeletal system; and sensory organ. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 95.0), liver E14 (RPKM 89.1) and 28 other tissues See more
Orthologs
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Genomic context

See Psma1 in Genome Data Viewer
Location:
7 F1; 7 59.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113863785..113875351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114264550..114276116, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene related RAS viral (r-ras) oncogene 2 Neighboring gene predicted gene, 53365 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene phosphodiesterase 3B, cGMP-inhibited Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proteasome subunit alpha type-1
Names
20S proteasome subunit C2
macropain subunit C2
multicatalytic endopeptidase complex subunit C2
proteasome (prosome, macropain) subunit, alpha type 1
proteasome component C2
proteasome nu chain
NP_036095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011965.2NP_036095.1  proteasome subunit alpha type-1

    See identical proteins and their annotated locations for NP_036095.1

    Status: VALIDATED

    Source sequence(s)
    AK162277, BY108158, BY425950
    Consensus CDS
    CCDS40094.1
    UniProtKB/Swiss-Prot
    Q9R1P4
    UniProtKB/TrEMBL
    A0A6P5PT12, A0A8C6N4D8, Q3TS44
    Related
    ENSMUSP00000033008.10, ENSMUST00000033008.10
    Conserved Domains (1) summary
    cd03749
    Location:6216
    proteasome_alpha_type_1; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113863785..113875351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)