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Psma1 proteasome (prosome, macropain) subunit, alpha type 1 [ Mus musculus (house mouse) ]

Gene ID: 26440, updated on 8-Jul-2018
Official Symbol
Psma1provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, alpha type 1provided by MGI
Primary source
MGI:MGI:1347005
See related
Ensembl:ENSMUSG00000030751 Vega:OTTMUSG00000025343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C2; HC2; Pros-30; alpha-type
Expression
Ubiquitous expression in placenta adult (RPKM 95.0), liver E14 (RPKM 89.1) and 28 other tissues See more
Orthologs
See Psma1 in Genome Data Viewer
Location:
7 F1; 7 59.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (114264550..114276116, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (121408064..121419630, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene related RAS viral (r-ras) oncogene 2 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene phosphodiesterase 3B, cGMP-inhibited Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
PubMed 
proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proteasome subunit alpha type-1
Names
20S proteasome subunit C2
macropain subunit C2
multicatalytic endopeptidase complex subunit C2
proteasome component C2
proteasome nu chain
NP_036095.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011965.2NP_036095.1  proteasome subunit alpha type-1

    See identical proteins and their annotated locations for NP_036095.1

    Status: VALIDATED

    Source sequence(s)
    AK162277, BY108158, BY425950
    Consensus CDS
    CCDS40094.1
    UniProtKB/Swiss-Prot
    Q9R1P4
    UniProtKB/TrEMBL
    Q3TS44
    Related
    ENSMUSP00000033008.9, OTTMUSP00000030740, ENSMUST00000033008.9, OTTMUST00000062381
    Conserved Domains (1) summary
    cd03749
    Location:6216
    proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    114264550..114276116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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