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Psma1 proteasome subunit alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 26440, updated on 1-Mar-2024

Summary

Official Symbol
Psma1provided by MGI
Official Full Name
proteasome subunit alpha 1provided by MGI
Primary source
MGI:MGI:1347005
See related
Ensembl:ENSMUSG00000030751 AllianceGenome:MGI:1347005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C2; HC2; Pros-30; alpha-type
Summary
Enables lipopolysaccharide binding activity. Involved in negative regulation of inflammatory response to antigenic stimulus. Part of proteasome core complex. Is expressed in several structures, including alimentary system; brain ventricular layer; cranial ganglion; musculoskeletal system; and sensory organ. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 95.0), liver E14 (RPKM 89.1) and 28 other tissues See more
Orthologs
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Genomic context

See Psma1 in Genome Data Viewer
Location:
7 F1; 7 59.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113863785..113875351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114264550..114276116, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene related RAS viral (r-ras) oncogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene phosphodiesterase 3B, cGMP-inhibited Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-1
Names
20S proteasome subunit C2
macropain subunit C2
multicatalytic endopeptidase complex subunit C2
proteasome (prosome, macropain) subunit, alpha type 1
proteasome component C2
proteasome nu chain
NP_036095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011965.2NP_036095.1  proteasome subunit alpha type-1

    See identical proteins and their annotated locations for NP_036095.1

    Status: VALIDATED

    Source sequence(s)
    AK162277, BY108158, BY425950
    Consensus CDS
    CCDS40094.1
    UniProtKB/Swiss-Prot
    Q9R1P4
    UniProtKB/TrEMBL
    Q3TS44, Q8BTU5
    Related
    ENSMUSP00000033008.10, ENSMUST00000033008.10
    Conserved Domains (1) summary
    cd03749
    Location:6216
    proteasome_alpha_type_1; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113863785..113875351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)