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Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 [ Mus musculus (house mouse) ]

Gene ID: 26433, updated on 26-Sep-2022

Summary

Official Symbol
Plod3provided by MGI
Official Full Name
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3provided by MGI
Primary source
MGI:MGI:1347008
See related
Ensembl:ENSMUSG00000004846 AllianceGenome:MGI:1347008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LH3
Summary
Enables procollagen glucosyltransferase activity and procollagen-lysine 5-dioxygenase activity. Involved in hydroxylysine biosynthetic process and peptidyl-lysine hydroxylation. Acts upstream of or within several processes, including chordate embryonic development; endothelial cell morphogenesis; and extracellular matrix organization. Located in several cellular components, including collagen-containing extracellular matrix; endoplasmic reticulum; and trans-Golgi network. Is expressed in several structures, including ear; hindlimb; incisor; nasal capsule; and skeleton. Orthologous to human PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 39.0), adrenal adult (RPKM 31.2) and 28 other tissues See more
Orthologs
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Genomic context

See Plod3 in Genome Data Viewer
Location:
5 G2; 5 76.09 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137015873..137025500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136987019..136996646)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene fission, mitochondrial 1 Neighboring gene claudin 15 Neighboring gene zinc finger, HIT domain containing 1 Neighboring gene microRNA 702 Neighboring gene 2-acylglycerol O-acyltransferase 2-A-like Neighboring gene predicted gene, 26989

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables procollagen galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables procollagen glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables procollagen glucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables procollagen glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within basement membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within collagen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydroxylysine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-lysine hydroxylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sequestering of metal ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Names
lysyl hydroxylase 2
lysyl hydroxylase 3
NP_036092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011962.3NP_036092.1  multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor

    See identical proteins and their annotated locations for NP_036092.1

    Status: VALIDATED

    Source sequence(s)
    BB692664, BC054734
    Consensus CDS
    CCDS19759.1
    UniProtKB/Swiss-Prot
    Q9CYY9, Q9R0E1
    Related
    ENSMUSP00000004968.5, ENSMUST00000004968.11
    Conserved Domains (1) summary
    smart00702
    Location:576739
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137015873..137025500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)