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Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [ Mus musculus (house mouse) ]

Gene ID: 26432, updated on 15-Nov-2022

Summary

Official Symbol
Plod2provided by MGI
Official Full Name
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2provided by MGI
Primary source
MGI:MGI:1347007
See related
Ensembl:ENSMUSG00000032374 AllianceGenome:MGI:1347007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LH2; Plod-2; D530025C14Rik
Summary
Predicted to enable procollagen-lysine 5-dioxygenase activity. Predicted to be involved in hydroxylysine biosynthetic process and peptidyl-lysine hydroxylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and skeleton. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 27.1), adrenal adult (RPKM 20.7) and 16 other tissues See more
Orthologs
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Genomic context

See Plod2 in Genome Data Viewer
Location:
9 E3.3; 9 48.4 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92421828..92490481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92539636..92608428)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 4 Neighboring gene RIKEN cDNA B430319G15 gene Neighboring gene predicted gene, 25417 Neighboring gene predicted gene 2495 Neighboring gene predicted gene 29396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in hydroxylysine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Names
lysyl hydroxylase 2
NP_001136388.1
NP_036091.2
XP_030100253.1
XP_036010914.1
XP_036010915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142916.1NP_001136388.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as LH2b).
    Source sequence(s)
    AC165156, AF080572, AK033363, AV488215, BB644981, CF615856
    Consensus CDS
    CCDS52887.1
    UniProtKB/Swiss-Prot
    Q9R0B9
    UniProtKB/TrEMBL
    E9Q718
    Related
    ENSMUSP00000125373.2, ENSMUST00000160359.2
    Conserved Domains (1) summary
    smart00702
    Location:593756
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  2. NM_011961.3NP_036091.2  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_036091.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2, also known as LH2a) missing a 21 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC165156, AF080572, AV488215, BB644981, CF615856
    Consensus CDS
    CCDS23408.1
    UniProtKB/Swiss-Prot
    Q8VDT4, Q9R0B9
    Related
    ENSMUSP00000068611.8, ENSMUST00000070522.14
    Conserved Domains (2) summary
    smart00702
    Location:572735
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    COG0463
    Location:347572
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    92421828..92490481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155022.1XP_036010915.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:220383
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  2. XM_030244393.2XP_030100253.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2

    Conserved Domains (1) summary
    smart00702
    Location:220383
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
  3. XM_036155021.1XP_036010914.1  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1