Git2 GIT ArfGAP 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Git2provided by MGI
Official Full Name: GIT ArfGAP 2provided by MGI
Primary source: MGI:MGI:1347053
See related: Ensembl:ENSMUSG00000041890 AllianceGenome:MGI:1347053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAT2; mKIAA0148; 1500036H07Rik; 5830420E16Rik; 6430510B20Rik; 9630056M03Rik; B230104M05Rik
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 38.4), lung adult (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 F

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114865469..114912647, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114727408..114774588, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A similar number of both total and gender-unique transcripts were significantly altered in response to GIT2 heterozygosity in early life-stage (2 month-old) mice
Title: Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.
GIT2(-/-) mice present a prematurely distorted thymic structure and dysfunction compared to age-matched 12 month-old wild-type control (C57BL/6) mice.
Title: Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.
GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage
Title: The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.
Title: The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
GIT2 has a key role in regulating the chemokine-mediated motility of double-positive thymocytes
Title: Regulation of thymocyte positive selection and motility by GIT2.
Results suggest that paxillin-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.
Title: Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration.
Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
Title: Anxiety-like behaviors in mice lacking GIT2.
Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.
Title: Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.
GIT2 links chemotaxis and superoxide production in neutrophils.Loss of GIT2 in vivo leads to an immunodeficient state.
Title: Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235271

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI851774 (e-PCR)
- UniSTS:207848

BE686802 (e-PCR)
- UniSTS:207856

Homology

Homologs of the Git2 gene: The Git2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 494 organisms have orthologs with human gene Git2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: ARF GTPase-activating protein GIT2

Names: ARF GAP GIT2; ARF GTPase activating protein 2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077359.1 → NP_001070827.1 ARF GTPase-activating protein GIT2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC087330, AK220323

UniProtKB/TrEMBL

Q5DU47

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:267 → 295

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:559 → 673

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_001077360.1 → NP_001070828.1 ARF GTPase-activating protein GIT2 isoform 3

See identical proteins and their annotated locations for NP_001070828.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC087330, BC056993

Consensus CDS

CCDS39223.1

UniProtKB/TrEMBL

Q6PGJ1, Q80XR8

Related

ENSMUSP00000039718.8, ENSMUST00000043283.14

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:558 → 672

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_001347400.1 → NP_001334329.1 ARF GTPase-activating protein GIT2 isoform 4

Status: VALIDATED

Source sequence(s)

AC087330

Consensus CDS

CCDS84939.1

UniProtKB/TrEMBL

E9PVA6

Related

ENSMUSP00000083754.5, ENSMUST00000086564.11
NM_019834.3 → NP_062808.3 ARF GTPase-activating protein GIT2 isoform 1

See identical proteins and their annotated locations for NP_062808.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC087330, AF148693, BC043062

Consensus CDS

CCDS19570.2

UniProtKB/Swiss-Prot

E9QPU7, Q9JLQ2

UniProtKB/TrEMBL

Q80XR8

Related

ENSMUSP00000107803.3, ENSMUST00000112185.9

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:587 → 701

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

114865469..114912647 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530331.4 → XP_006530394.1 ARF GTPase-activating protein GIT2 isoform X2

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:267 → 295

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:639 → 753

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:415 → 479

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530334.4 → XP_006530397.1 ARF GTPase-activating protein GIT2 isoform X4

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:625 → 739

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:416 → 465

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530335.4 → XP_006530398.1 ARF GTPase-activating protein GIT2 isoform X7

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:610 → 724

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:416 → 480

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530339.4 → XP_006530402.1 ARF GTPase-activating protein GIT2 isoform X1

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:640 → 754

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:416 → 480

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_030254527.1 → XP_030110387.1 ARF GTPase-activating protein GIT2 isoform X17

Related

ENSMUSP00000136796.2, ENSMUST00000178440.8

Conserved Domains (5) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:557 → 671

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)
XM_030254522.2 → XP_030110382.1 ARF GTPase-activating protein GIT2 isoform X6

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:622 → 736

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:413 → 462

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530333.5 → XP_006530396.1 ARF GTPase-activating protein GIT2 isoform X3

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:637 → 751

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:413 → 477

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_017320893.3 → XP_017176382.1 ARF GTPase-activating protein GIT2 isoform X12

Conserved Domains (5) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:588 → 702

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)
XM_030254520.2 → XP_030110380.1 ARF GTPase-activating protein GIT2 isoform X5

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:623 → 737

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 463

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530336.5 → XP_006530399.1 ARF GTPase-activating protein GIT2 isoform X8

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:608 → 722

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 478

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_006530338.5 → XP_006530401.1 ARF GTPase-activating protein GIT2 isoform X16

UniProtKB/TrEMBL

D3Z1I2

Related

ENSMUSP00000107801.2, ENSMUST00000112183.8

Conserved Domains (5) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:560 → 674

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)
XM_006530337.5 → XP_006530400.1 ARF GTPase-activating protein GIT2 isoform X11

Conserved Domains (5) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:590 → 704

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)
XM_030254524.2 → XP_030110384.1 ARF GTPase-activating protein GIT2 isoform X10

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:595 → 709

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:416 → 465

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_030254526.2 → XP_030110386.1 ARF GTPase-activating protein GIT2 isoform X15

Conserved Domains (6) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:203 → 231

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:575 → 689

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:351 → 415

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_036165144.1 → XP_036021037.1 ARF GTPase-activating protein GIT2 isoform X14

Conserved Domains (6) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:204 → 232

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:574 → 690

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:352 → 416

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_030254525.2 → XP_030110385.1 ARF GTPase-activating protein GIT2 isoform X13

Conserved Domains (6) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:206 → 234

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:578 → 692

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:354 → 418

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_030254529.2 → XP_030110389.1 ARF GTPase-activating protein GIT2 isoform X19

Conserved Domains (5) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:203 → 231

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:525 → 639

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)
XM_030254530.2 → XP_030110390.1 ARF GTPase-activating protein GIT2 isoform X20

Conserved Domains (5) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:204 → 232

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:496 → 610

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)
XM_030254528.2 → XP_030110388.1 ARF GTPase-activating protein GIT2 isoform X18

Conserved Domains (5) summary

sd00045
Location:75 → 103

ANK; ANK repeat [structural motif]

cl28907
Location:1 → 49

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

pfam08518
Location:204 → 232

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:526 → 640

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:75 → 167

Ank_2; Ankyrin repeats (3 copies)
XM_030254523.2 → XP_030110383.1 ARF GTPase-activating protein GIT2 isoform X9

Related

ENSMUSP00000122302.3, ENSMUST00000155908.8

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:607 → 721

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:413 → 477

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor