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Nr5a1 nuclear receptor subfamily 5, group A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 26423, updated on 14-Oct-2021

Summary

Official Symbol
Nr5a1provided by MGI
Official Full Name
nuclear receptor subfamily 5, group A, member 1provided by MGI
Primary source
MGI:MGI:1346833
See related
Ensembl:ENSMUSG00000026751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ELP; SF1; SF-1; Ad4BP; ELP-3; Ftzf1; STF-1; Ftz-F1
Expression
Restricted expression toward adrenal adult (RPKM 325.2) See more
Orthologs
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Genomic context

See Nr5a1 in Genome Data Viewer
Location:
2 B; 2 24.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38582668..38604554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38692656..38714542, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (38548180..38570062, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744 Neighboring gene Nr5a1 enhancer region in intron 6 Neighboring gene Nr5a1 enhancer in intron 4 Neighboring gene Nr5a1 5' regulatory region Neighboring gene nuclear receptor subfamily 6, group A, member 1 Neighboring gene nuclear receptor subfamily 6, group A, member 1, opposite strand Neighboring gene microRNA 181a-2 Neighboring gene microRNA 181b-2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124277, MGC124278

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcineurin-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in female gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within luteinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in male sex determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sex determination ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
steroidogenic factor 1
Names
adrenal 4-binding protein
embryonal LTR-binding protein
embryonal long terminal repeat-binding protein
fushi tarazu 1 factor homolog
fushi tarazu factor homolog 1
steroid hormone receptor Ad4BP
steroid hydroxylase positive regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316687.1NP_001303616.1  steroidogenic factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK134378, AL844842, CD348290
    Consensus CDS
    CCDS16011.1
    UniProtKB/Swiss-Prot
    P33242
    Related
    ENSMUSP00000108504.2, ENSMUST00000112883.8
    Conserved Domains (3) summary
    cd07070
    Location:237460
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    pfam15822
    Location:147217
    MISS; MAPK-interacting and spindle-stabilizing protein-like
  2. NM_139051.3NP_620639.1  steroidogenic factor 1

    See identical proteins and their annotated locations for NP_620639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK134378
    Consensus CDS
    CCDS16011.1
    UniProtKB/Swiss-Prot
    P33242
    Related
    ENSMUSP00000028084.5, ENSMUST00000028084.5
    Conserved Domains (3) summary
    cd07070
    Location:237460
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    pfam15822
    Location:147217
    MISS; MAPK-interacting and spindle-stabilizing protein-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38582668..38604554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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