GCGR glucagon receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: GCGRprovided by HGNC
Official Full Name: glucagon receptorprovided by HGNC
Primary source: HGNC:HGNC:4192
See related: Ensembl:ENSG00000215644 MIM:138033; AllianceGenome:HGNC:4192
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GGR; GL-R; MVAH
Summary: The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Expression: Biased expression in liver (RPKM 10.3), kidney (RPKM 5.0) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81804150..81814008)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82671316..82681173)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79762026..79771884)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes.
Title: Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes.
Hepatocyte cholesterol content modulates glucagon receptor signalling.
Title: Hepatocyte cholesterol content modulates glucagon receptor signalling.
Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes.
Title: Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes.
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
Title: Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for (19) F-NMR studies in solution.
Title: Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for (19) F-NMR studies in solution.
Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.
Title: Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.
Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.
Title: Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.
Title: Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.
A combined activation mechanism for the glucagon receptor.
Title: A combined activation mechanism for the glucagon receptor.
the structures of the glucagon receptor (GCGR) bound to glucagon and distinct classes of heterotrimeric G proteins, Gs or Gi1 was determined using cryo-electron microscopy
Title: Structural basis of G(s) and G(i) recognition by the human glucagon receptor.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
GCGR-related hyperglucagonemia MedGen: C4763635 OMIM: 619290 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103588 (e-PCR)
- UniSTS:97913

NoName (e-PCR)
- UniSTS:483745

MARC_14771-14772:1010669884:1 (e-PCR)
- UniSTS:267730

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucagon stimulus	TAS Traceable Author Statement more info
acts_upstream_of_or_within cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glycogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient	TAS Traceable Author Statement more info	PubMed
involved_in response to starvation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glucagon receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016409.1 RefSeqGene

Range

2977..12835

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000160.5 → NP_000151.1 glucagon receptor precursor

See identical proteins and their annotated locations for NP_000151.1

Status: REVIEWED

Source sequence(s)

BC104854, DA639395, L20316, U03469

Consensus CDS

CCDS54177.1

UniProtKB/Swiss-Prot

P47871, Q2M3M5

Related

ENSP00000383558.3, ENST00000400723.8

Conserved Domains (2) summary

cd15267
Location:136 → 410

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:55 → 122

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81804150..81814008

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024446.2 → XP_016879935.1 glucagon receptor isoform X2
XM_006722277.2 → XP_006722340.1 glucagon receptor isoform X1

See identical proteins and their annotated locations for XP_006722340.1

UniProtKB/Swiss-Prot

P47871, Q2M3M5

Conserved Domains (2) summary

cd15267
Location:136 → 410

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:55 → 122

HRM; Hormone receptor domain
XM_011523539.2 → XP_011521841.1 glucagon receptor isoform X3

Conserved Domains (1) summary

pfam00002
Location:105 → 363

7tm_2; 7 transmembrane receptor (Secretin family)