Format

Send to:

Choose Destination

GCGR glucagon receptor [ Homo sapiens (human) ]

Gene ID: 2642, updated on 11-Sep-2019

Summary

Official Symbol
GCGRprovided by HGNC
Official Full Name
glucagon receptorprovided by HGNC
Primary source
HGNC:HGNC:4192
See related
Ensembl:ENSG00000215644 MIM:138033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGR; GL-R
Summary
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Expression
Biased expression in liver (RPKM 10.3), kidney (RPKM 5.0) and 1 other tissue See more
Orthologs

Genomic context

See GCGR in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81804078..81814008)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79762010..79771889)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene MAPK regulated corepressor interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Glucagon signaling in metabolic regulation, organism-specific biosystem (from REACTOME)
    Glucagon signaling in metabolic regulation, organism-specific biosystemGlucagon and insulin are peptide hormones released from the pancreas into the blood, that normally act in complementary fashion to stabilize blood glucose concentration. When blood glucose levels ris...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
    Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97182, MGC138246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucagon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucagon receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucagon stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of glycogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nutrient TAS
Traceable Author Statement
more info
PubMed 
response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016409.1 RefSeqGene

    Range
    2977..12835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000160.5NP_000151.1  glucagon receptor precursor

    See identical proteins and their annotated locations for NP_000151.1

    Status: REVIEWED

    Source sequence(s)
    BC104854, DA639395, L20316, U03469
    Consensus CDS
    CCDS54177.1
    UniProtKB/Swiss-Prot
    P47871
    Related
    ENSP00000383558.3, ENST00000400723.8
    Conserved Domains (2) summary
    pfam02793
    Location:55122
    HRM; Hormone receptor domain
    cd15267
    Location:136410
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81804078..81814008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024446.1XP_016879935.1  glucagon receptor isoform X2

  2. XM_011523539.1XP_011521841.1  glucagon receptor isoform X3

    Conserved Domains (1) summary
    pfam00002
    Location:105363
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. XM_006722277.1XP_006722340.1  glucagon receptor isoform X1

    See identical proteins and their annotated locations for XP_006722340.1

    UniProtKB/Swiss-Prot
    P47871
    Conserved Domains (2) summary
    pfam02793
    Location:55122
    HRM; Hormone receptor domain
    cd15267
    Location:136410
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  4. XM_017024447.1XP_016879936.1  glucagon receptor isoform X4

    Conserved Domains (1) summary
    pfam00002
    Location:16274
    7tm_2; 7 transmembrane receptor (Secretin family)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p13 PATCHES

    Range
    17643..27501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center