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GCGR glucagon receptor [ Homo sapiens (human) ]

Gene ID: 2642, updated on 3-Feb-2021

Summary

Official Symbol
GCGRprovided by HGNC
Official Full Name
glucagon receptorprovided by HGNC
Primary source
HGNC:HGNC:4192
See related
Ensembl:ENSG00000215644 MIM:138033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGR; GL-R
Summary
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Expression
Biased expression in liver (RPKM 10.3), kidney (RPKM 5.0) and 1 other tissue See more
Orthologs
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Genomic context

See GCGR in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81804078..81814008)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79762026..79771884)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene MAPK regulated corepressor interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97182, MGC138246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucagon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucagon receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucagon stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nutrient TAS
Traceable Author Statement
more info
PubMed 
response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016409.1 RefSeqGene

    Range
    2977..12835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000160.5NP_000151.1  glucagon receptor precursor

    See identical proteins and their annotated locations for NP_000151.1

    Status: REVIEWED

    Source sequence(s)
    BC104854, DA639395, L20316, U03469
    Consensus CDS
    CCDS54177.1
    UniProtKB/Swiss-Prot
    P47871
    Related
    ENSP00000383558.3, ENST00000400723.8
    Conserved Domains (2) summary
    pfam02793
    Location:55122
    HRM; Hormone receptor domain
    cd15267
    Location:136410
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81804078..81814008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024446.1XP_016879935.1  glucagon receptor isoform X2

  2. XM_011523539.1XP_011521841.1  glucagon receptor isoform X3

    Conserved Domains (1) summary
    pfam00002
    Location:105363
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. XM_006722277.1XP_006722340.1  glucagon receptor isoform X1

    See identical proteins and their annotated locations for XP_006722340.1

    UniProtKB/Swiss-Prot
    P47871
    Conserved Domains (2) summary
    pfam02793
    Location:55122
    HRM; Hormone receptor domain
    cd15267
    Location:136410
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  4. XM_017024447.1XP_016879936.1  glucagon receptor isoform X4

    Conserved Domains (1) summary
    pfam00002
    Location:16274
    7tm_2; 7 transmembrane receptor (Secretin family)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p13 PATCHES

    Range
    17643..27501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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