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Mapk8 mitogen-activated protein kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 26419, updated on 8-Feb-2024

Summary

Official Symbol
Mapk8provided by MGI
Official Full Name
mitogen-activated protein kinase 8provided by MGI
Primary source
MGI:MGI:1346861
See related
Ensembl:ENSMUSG00000021936 AllianceGenome:MGI:1346861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JNK; JNK1; Prkm8; SAPK1
Summary
Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 19.1), CNS E14 (RPKM 18.4) and 26 other tissues See more
Orthologs
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Genomic context

See Mapk8 in Genome Data Viewer
Location:
14 B; 14 20.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33099855..33169213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33377898..33447353, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene Rho GTPase activating protein 22 Neighboring gene predicted pseudogene 6340 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 20

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within JUN phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within JUN phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to biotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxygen-glucose deprivation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to tricellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dense core granule transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cadmium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basal dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 8
Names
JNK1 beta1 protein kinase
MAP kinase 8
MAPK 8
c-Jun N-terminal kinase 1
protein kinase mitogen-activated 8
stress-activated protein kinase JNK1
NP_001297381.1
NP_001297382.1
NP_001297383.1
NP_057909.1
XP_030103680.1
XP_036014495.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310452.2NP_001297381.1  mitogen-activated protein kinase 8 isoform 2

    See identical proteins and their annotated locations for NP_001297381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and both contains and lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2 which is the same length as isoform 1, but differs in a small segment in the central region of the protein, compared to isoform 1.
    Source sequence(s)
    AC154649
    Consensus CDS
    CCDS84111.1
    UniProtKB/Swiss-Prot
    Q61831, Q9R0U6
    UniProtKB/TrEMBL
    A6P3E4
    Related
    ENSMUSP00000107574.2, ENSMUST00000111943.8
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001310453.2NP_001297382.1  mitogen-activated protein kinase 8 isoform 4

    See identical proteins and their annotated locations for NP_001297382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) both contains and lacks an alternate in-frame exon in the central coding region, and uses an alternate splice donor site in its 3' terminal exon which results in a frameshift, compared to variant 1. It encodes isoform 4 has an alternate region in the central region of the protein and a longer and distinct C-terminus, compared to isoform 1. Isoforms 3 and 4 are the same length, but differ in a small segment in the central region of the protein.
    Source sequence(s)
    AC154649
    Consensus CDS
    CCDS79293.1
    UniProtKB/TrEMBL
    G3X8U9
    Related
    ENSMUSP00000022504.6, ENSMUST00000022504.12
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. NM_001310454.2NP_001297383.1  mitogen-activated protein kinase 8 isoform 3

    See identical proteins and their annotated locations for NP_001297383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice donor site in its 3' terminal exon which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1. Isoforms 3 and 4 are the same length, but differ in a small segment in the central region of the protein.
    Source sequence(s)
    AC154649
    Consensus CDS
    CCDS79295.1
    UniProtKB/TrEMBL
    Q7TSJ7
    Related
    ENSMUSP00000107575.4, ENSMUST00000111944.10
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. NM_016700.5NP_057909.1  mitogen-activated protein kinase 8 isoform 1

    See identical proteins and their annotated locations for NP_057909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Isoforms 1 and 2 are the same length, but differ in a small segment in the central region of the protein.
    Source sequence(s)
    AC154649
    Consensus CDS
    CCDS36869.1
    UniProtKB/Swiss-Prot
    Q61831, Q91Y86, Q9R0U6
    UniProtKB/TrEMBL
    Q544A0
    Related
    ENSMUSP00000107576.3, ENSMUST00000111945.9
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. NR_188805.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154649

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33099855..33169213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158602.1XP_036014495.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030247820.2XP_030103680.1  mitogen-activated protein kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain