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Mapk3 mitogen-activated protein kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 26417, updated on 24-Sep-2025
Official Symbol
Mapk3provided by MGI
Official Full Name
mitogen-activated protein kinase 3provided by MGI
Primary source
MGI:MGI:1346859
See related
Ensembl:ENSMUSG00000063065 AllianceGenome:MGI:1346859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk
Summary
Enables MAP kinase activity and phosphotyrosine residue binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and respiratory system development. Located in cytosol; nucleus; and pseudopodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in colon adult (RPKM 245.8), large intestine adult (RPKM 217.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See Mapk3 in Genome Data Viewer
Location:
7 F3; 7 69.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126358798..126364988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126759626..126765816)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133845996-133846179 Neighboring gene STARR-positive B cell enhancer ABC_E10475 Neighboring gene coronin, actin binding protein 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133851295-133851448 Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_20155 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E6602 Neighboring gene yippee like 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac neural crest cell development involved in heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in caveolin-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-34-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-34-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell mediated immune response to tumor cell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within outer ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuroinflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of xenophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein stabilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Golgi inheritance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in response to epidermal growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to epidermal growth factor ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in caveola IEA
Inferred from Electronic Annotation
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mitogen-activated protein kinase 3
Names
MAP kinase 3
extracellular signal-regulated kinase 1
insulin-stimulated MAP2 kinase
microtubule-associated protein 2 kinase
p44 MAP kinase
pp42/MAP kinase
NP_036082.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011952.2NP_036082.1  mitogen-activated protein kinase 3

    See identical proteins and their annotated locations for NP_036082.1

    Status: VALIDATED

    Source sequence(s)
    BC029712, BQ929318
    Consensus CDS
    CCDS21841.1
    UniProtKB/Swiss-Prot
    Q61531, Q63844, Q8K0X5, Q91YW5
    UniProtKB/TrEMBL
    A0A0U1RPX4
    Related
    ENSMUSP00000051619.10, ENSMUST00000057669.16
    Conserved Domains (1) summary
    cd07849
    Location:37371
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126358798..126364988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)