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Ift56 intraflagellar transport 56 [ Mus musculus (house mouse) ]

Gene ID: 264134, updated on 12-May-2024

Summary

Official Symbol
Ift56provided by MGI
Official Full Name
intraflagellar transport 56provided by MGI
Primary source
MGI:MGI:2444853
See related
Ensembl:ENSMUSG00000056832 AllianceGenome:MGI:2444853
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hop; hpy; Ttc26; 9330141E21Rik; 9430097H08Rik
Summary
Enables intraciliary transport particle B binding activity. Involved in cilium organization; protein localization to cilium; and smoothened signaling pathway. Acts upstream of or within manchette assembly. Located in centrosome and ciliary basal body. Part of intraciliary transport particle B. Orthologous to human TTC26 (tetratricopeptide repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.0), CNS E11.5 (RPKM 2.9) and 16 other tissues See more
Orthologs
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Genomic context

See Ift56 in Genome Data Viewer
Location:
6 B1; 6 17.76 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38358400..38404582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38381464..38427647)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15622 Neighboring gene UPF0547 protein C16orf87 homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38331316-38331499 Neighboring gene ribosomal protein L30, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38383641-38383885 Neighboring gene predicted gene, 53284 Neighboring gene ubinuclein 2 Neighboring gene microRNA 7670 Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
hop-sterile
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28016

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intraciliary transport particle B binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intraciliary transport particle B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intraciliary anterograde transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intraciliary anterograde transport IC
Inferred by Curator
more info
PubMed 
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intraciliary transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within manchette assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within photoreceptor cell morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cilium NAS
Non-traceable Author Statement
more info
PubMed 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
intraflagellar transport protein 56
Names
TPR repeat protein 26
hydrocephalic-polydactyl
protein hop-sterile
tetratricopeptide repeat domain 26
tetratricopeptide repeat protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153600.2NP_705828.2  intraflagellar transport protein 56

    See identical proteins and their annotated locations for NP_705828.2

    Status: PROVISIONAL

    Source sequence(s)
    BC066060
    Consensus CDS
    CCDS51750.1
    UniProtKB/Swiss-Prot
    Q8BS45
    Related
    ENSMUSP00000124369.2, ENSMUST00000162554.8
    Conserved Domains (2) summary
    TIGR02917
    Location:33346
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:5886
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38358400..38404582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506152.5XP_006506215.1  intraflagellar transport protein 56 isoform X1

    Conserved Domains (2) summary
    TIGR02917
    Location:33346
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:5886
    TPR; TPR repeat [structural motif]

RNA

  1. XR_003956200.2 RNA Sequence

    Related
    ENSMUST00000159145.8