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Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26411, updated on 3-Apr-2024

Summary

Official Symbol
Map4k1provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 1provided by MGI
Primary source
MGI:MGI:1346882
See related
Ensembl:ENSMUSG00000037337 AllianceGenome:MGI:1346882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpk1; mHPK1
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 40.1), thymus adult (RPKM 25.1) and 10 other tissues See more
Orthologs
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Genomic context

See Map4k1 in Genome Data Viewer
Location:
7 B1; 7 16.94 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28681506..28702704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28982050..29003279)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene predicted gene, 51446 Neighboring gene STARR-seq mESC enhancer starr_18451 Neighboring gene STARR-positive B cell enhancer ABC_E698 Neighboring gene STARR-positive B cell enhancer ABC_E1729 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene STARR-positive B cell enhancer ABC_E10432 Neighboring gene predicted gene, 38979 Neighboring gene predicted gene, 26604

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 1
Names
HPK
MAPK/ERK kinase kinase kinase 1
MEK kinase kinase 1
MEKKK 1
hematopoietic progenitor kinase 1
NP_001341983.1
NP_001414092.1
NP_001414093.1
NP_001414094.1
NP_001414095.1
NP_032305.2
XP_006540059.1
XP_006540061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355054.2NP_001341983.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
    Consensus CDS
    CCDS90193.1
    UniProtKB/TrEMBL
    Q3UJX3, Q3UPT4
    Related
    ENSMUSP00000146807.2, ENSMUST00000208227.2
    Conserved Domains (2) summary
    smart00036
    Location:460735
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:1228
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. NM_001427163.1NP_001414092.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
  3. NM_001427164.1NP_001414093.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
  4. NM_001427165.1NP_001414094.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
  5. NM_001427166.1NP_001414095.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
  6. NM_008279.3NP_032305.2  mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_032305.2

    Status: VALIDATED

    Source sequence(s)
    AC165142, AC166357
    Consensus CDS
    CCDS39865.1
    UniProtKB/Swiss-Prot
    P70218, Q8R3R0, Q99K62
    UniProtKB/TrEMBL
    Q3UJX3
    Related
    ENSMUSP00000082995.7, ENSMUST00000085835.8
    Conserved Domains (3) summary
    smart00036
    Location:506813
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28681506..28702704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539998.3XP_006540061.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X5

    UniProtKB/TrEMBL
    Q3UJX3
    Conserved Domains (2) summary
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    cl02434
    Location:506751
    CNH; CNH domain
  2. XM_006539996.2XP_006540059.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q3UJX3
    Conserved Domains (2) summary
    smart00036
    Location:506783
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases