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Map3k8 mitogen-activated protein kinase kinase kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 26410, updated on 30-Nov-2021

Summary

Official Symbol
Map3k8provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 8provided by MGI
Primary source
MGI:MGI:1346878
See related
Ensembl:ENSMUSG00000024235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cot; Est; Estf; Tpl2; Tpl-2; c-COT; Cot/Tpl2
Expression
Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues See more
Orthologs
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Genomic context

See Map3k8 in Genome Data Viewer
Location:
18 A1; 18 2.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4331325..4352978, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4331325..4352953, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (4331325..4352951, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41657 Neighboring gene carbohydrate sulfotransferase 10 pseudogene Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene mitochondrial poly(A) polymerase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Chemically induced (ENU) (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 8
Names
COT proto-oncogene serine/threonine-protein kinase
cancer Osaka thyroid oncogene
proto-oncogene c-Cot
serine/threonine-protein kinase cot
tumor progression locus 2
NP_031772.1
XP_006526007.1
XP_036017050.1
XP_036017051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007746.2NP_031772.1  mitogen-activated protein kinase kinase kinase 8

    See identical proteins and their annotated locations for NP_031772.1

    Status: VALIDATED

    Source sequence(s)
    AC138768
    Consensus CDS
    CCDS29036.1
    UniProtKB/Swiss-Prot
    Q07174
    UniProtKB/TrEMBL
    Q3UEB8
    Related
    ENSMUSP00000025078.3, ENSMUST00000025078.10
    Conserved Domains (2) summary
    smart00220
    Location:146386
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13995
    Location:133388
    STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

RNA

  1. NR_157375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK140334, AK171403
    Related
    ENSMUST00000173930.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4331325..4352978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161157.1XP_036017050.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:80211
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006525944.3XP_006526007.1  mitogen-activated protein kinase kinase kinase 8 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:2231
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036161158.1XP_036017051.1  mitogen-activated protein kinase kinase kinase 8 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:65196
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003952522.2 RNA Sequence

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