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Map3k7 mitogen-activated protein kinase kinase kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 26409, updated on 8-Feb-2024

Summary

Official Symbol
Map3k7provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 7provided by MGI
Primary source
MGI:MGI:1346877
See related
Ensembl:ENSMUSG00000028284 AllianceGenome:MGI:1346877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tak1; B430101B05
Summary
Enables enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.0) and 28 other tissues See more
Orthologs
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Genomic context

See Map3k7 in Genome Data Viewer
Location:
4 A5; 4 13.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (31963659..32023470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (31963492..32023470)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42315 Neighboring gene STARR-seq mESC enhancer starr_09843 Neighboring gene STARR-seq mESC enhancer starr_09845 Neighboring gene STARR-seq mESC enhancer starr_09846 Neighboring gene STARR-seq mESC enhancer starr_09848 Neighboring gene predicted gene, 32412 Neighboring gene STARR-seq mESC enhancer starr_09849 Neighboring gene STARR-positive B cell enhancer ABC_E6156 Neighboring gene STARR-seq mESC enhancer starr_09851 Neighboring gene STARR-seq mESC enhancer starr_09853 Neighboring gene STARR-seq mESC enhancer starr_09854 Neighboring gene predicted gene, 26254 Neighboring gene STARR-positive B cell enhancer ABC_E7958 Neighboring gene STARR-positive B cell enhancer ABC_E10228 Neighboring gene predicted gene 11927 Neighboring gene STARR-seq mESC enhancer starr_09855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32251946-32252191 Neighboring gene STARR-seq mESC enhancer starr_09857 Neighboring gene STARR-seq mESC enhancer starr_09858 Neighboring gene predicted gene, 42266

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within I-kappaB phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-17A-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 7
Names
TGF-beta-activated kinase 1
transforming growth factor-beta-activated kinase 1
NP_033342.1
NP_766276.1
XP_006538011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009316.1NP_033342.1  mitogen-activated protein kinase kinase kinase 7 isoform B

    See identical proteins and their annotated locations for NP_033342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    AK137046, AL833781, CV559615
    Consensus CDS
    CCDS51133.1
    UniProtKB/TrEMBL
    Q3TXG1, Q923A8
    Related
    ENSMUSP00000040307.5, ENSMUST00000037607.11
    Conserved Domains (1) summary
    cd14058
    Location:42292
    STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
  2. NM_172688.3NP_766276.1  mitogen-activated protein kinase kinase kinase 7 isoform A

    See identical proteins and their annotated locations for NP_766276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) lacks an in-frame coding segment, compared to variant B. The resulting isoform (A) lacks an internal region, as compared to isoform B.
    Source sequence(s)
    AK137046, AL833781
    Consensus CDS
    CCDS18014.1
    UniProtKB/Swiss-Prot
    Q62073
    UniProtKB/TrEMBL
    Q3TXG1, Q543B5
    Related
    ENSMUSP00000079734.7, ENSMUST00000080933.13
    Conserved Domains (1) summary
    cd14058
    Location:42292
    STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    31963659..32023470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537948.4XP_006538011.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1162
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_390323.5 RNA Sequence

  2. XR_004941909.1 RNA Sequence

  3. XR_004941907.1 RNA Sequence

  4. XR_004941908.1 RNA Sequence