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Cdk8 cyclin-dependent kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 264064, updated on 13-Dec-2022

Summary

Official Symbol
Cdk8provided by MGI
Official Full Name
cyclin-dependent kinase 8provided by MGI
Primary source
MGI:MGI:1196224
See related
Ensembl:ENSMUSG00000029635 AllianceGenome:MGI:1196224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Part of mediator complex. Is expressed in embryo. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk8 in Genome Data Viewer
Location:
5; 5 G3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146167432..146239684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146230795..146302874)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ring finger protein (C3H2C3 type) 6 Neighboring gene predicted gene, 38745 Neighboring gene predicted gene, 52832 Neighboring gene predicted gene, 38747

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37111

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 8
Names
cell division protein kinase 8
mediator complex subunit CDK8
mediator of RNA polymerase II transcription subunit CDK8
NP_001346919.1
NP_001346920.1
NP_705827.2
XP_006504899.1
XP_006504901.1
XP_006504902.1
XP_006504903.1
XP_030110375.1
XP_036021035.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359990.1NP_001346919.1  cyclin-dependent kinase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC113316
    UniProtKB/TrEMBL
    A0A6P5PPK0
    Conserved Domains (1) summary
    cd07868
    Location:3335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
  2. NM_001359991.1NP_001346920.1  cyclin-dependent kinase 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC113316, AK131948
    Consensus CDS
    CCDS90018.1
    UniProtKB/TrEMBL
    E9Q6E2
    Related
    ENSMUSP00000125668.2, ENSMUST00000161181.8
    Conserved Domains (1) summary
    cl21453
    Location:1270
    PKc_like; Protein Kinases, catalytic domain
  3. NM_153599.4NP_705827.2  cyclin-dependent kinase 8 isoform 1

    See identical proteins and their annotated locations for NP_705827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113316
    Consensus CDS
    CCDS19869.1
    UniProtKB/Swiss-Prot
    Q8R3L8
    UniProtKB/TrEMBL
    A0A6P5PJZ8, A0A8C6I0D2
    Related
    ENSMUSP00000031640.9, ENSMUST00000031640.15
    Conserved Domains (1) summary
    cd07868
    Location:3335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146167432..146239684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504836.5XP_006504899.1  cyclin-dependent kinase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R3L8
    Conserved Domains (1) summary
    cl21453
    Location:3330
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006504840.5XP_006504903.1  cyclin-dependent kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A8C6I150
    Conserved Domains (1) summary
    cl21453
    Location:3287
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030254515.2XP_030110375.1  cyclin-dependent kinase 8 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:3287
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006504838.5XP_006504901.1  cyclin-dependent kinase 8 isoform X2

    UniProtKB/TrEMBL
    A0A6P5PSD1
    Conserved Domains (1) summary
    cl21453
    Location:3322
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006504839.5XP_006504902.1  cyclin-dependent kinase 8 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:3298
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036165142.1XP_036021035.1  cyclin-dependent kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:3298
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181570.1: Suppressed sequence

    Description
    NM_181570.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.