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Map3k11 mitogen-activated protein kinase kinase kinase 11 [ Mus musculus (house mouse) ]

Gene ID: 26403, updated on 19-Mar-2023

Summary

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Official Symbol
Map3k11provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 11provided by MGI
Primary source
MGI:MGI:1346880
See related
Ensembl:ENSMUSG00000004054 AllianceGenome:MGI:1346880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlk3; PTK1; SPRK; 2610017K16Rik
Summary
Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Predicted to be involved in several processes, including JNK cascade; positive regulation of MAPK cascade; and positive regulation of neuron apoptotic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in microtubule. Predicted to be active in centrosome. Is expressed in blood vessel and brain. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 55.6), duodenum adult (RPKM 45.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Map3k11 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5738439..5752893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5688411..5702865)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation associated gene 1 Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene family with sequence similarity 89, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. Liu PW, et al. Am J Physiol Heart Circ Physiol, 2022 Sep 1. PMID 35867711,
  2. Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis. Chen X, et al. J Mol Histol, 2022 Apr. PMID 35247112
  3. MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms. Calamaras TD, et al. JCI Insight, 2021 Sep 22. PMID 34324442, Free PMC Article
  4. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Wang J, et al. Cell Death Dis, 2020 Jul 24. PMID 32710001, Free PMC Article
  5. Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders. Zhang Y, et al. Brain Res, 2020 Jan 1. PMID 31654642

See all (68) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells.
    Title: MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells.
  2. Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function.
    Title: Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function.
  3. Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis.
    Title: Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis.
  4. MLK3 mediates impact of PKG1alpha on cardiac function and controls blood pressure through separate mechanisms.
    Title: MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms.
  5. Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.
    Title: Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.
  6. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
    Title: Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
  7. Study identified that genetic loss/inhibition of a MLK3, increases CD8+ T cell cytotoxicity via inhibition of a prolyl isomerase, Ppia, and nuclear translocation of NFATc1. The MLK3 inhibitor increased the tumor infiltration of cytotoxic T cells in an immune-competent mouse model of breast cancer and increased the cytotoxic T cell population in pan T cells isolated from breast cancer patients with metastatic disease.
    Title: Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
  8. This study is the first to identify GNAI2 as a promising target for prevention of hepatic I/R-induced injury and related liver diseases
    Title: Guanine nucleotide-binding protein G(i)α2 aggravates hepatic ischemia-reperfusion injury in mice by regulating MLK3 signaling.
  9. MLK3-/- mice exhibited baseline cardiac hypertrophy with preserved cardiac function. MLK3-/- mice subjected to chronic left ventricular pressure overload developed worsened cardiac dysfunction.
    Title: Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.
  10. In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation.
    Title: Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables JUN kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 11
Names
mixed lineage kinase 3
NP_071295.2
XP_006531815.1
XP_006531816.1
XP_030106811.1
XP_030106812.1
XP_030106813.1
XP_036017492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418343.1 → NP_001405272.1  mitogen-activated protein kinase kinase kinase 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134563

  2. NM_001418344.1 → NP_001405273.1  mitogen-activated protein kinase kinase kinase 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134563

  3. NM_001418345.1 → NP_001405274.1  mitogen-activated protein kinase kinase kinase 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134563

  4. NM_022012.4 → NP_071295.2  mitogen-activated protein kinase kinase kinase 11 isoform 1

    See identical proteins and their annotated locations for NP_071295.2

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29476.1
    UniProtKB/Swiss-Prot
    Q80XI6, Q9JJ15
    Related
    ENSMUSP00000004156.9, ENSMUST00000004156.10
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5738439..5752893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250953.1 → XP_030106813.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJ15
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

  2. XM_030250951.2 → XP_030106811.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJ15
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

  3. XM_030250952.1 → XP_030106812.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJ15
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

  4. XM_006531752.2 → XP_006531815.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q80XI6, Q9JJ15
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

  5. XM_036161599.1 → XP_036017492.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9JJ15
    Conserved Domains (2) summary
    cd12059
    Location:46 → 103
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14147
    Location:114 → 380
    STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

  6. XM_006531753.5 → XP_006531816.1  mitogen-activated protein kinase kinase kinase 11 isoform X2

    Conserved Domains (3) summary
    PHA03307
    Location:310 → 574
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:118 → 205
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl21453
    Location:1 → 122
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004940149.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XI6.1 GenPept UniProtKB/Swiss-Prot:Q80XI6

Gene LinkOut

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