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Map2k1 mitogen-activated protein kinase kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26395, updated on 8-Feb-2024

Summary

Official Symbol
Map2k1provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 1provided by MGI
Primary source
MGI:MGI:1346866
See related
Ensembl:ENSMUSG00000004936 AllianceGenome:MGI:1346866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mek1; MEKK1; MAPKK1; Prkmk1
Summary
Enables MAP kinase kinase activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and neurogenesis. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 50.3), cortex adult (RPKM 32.1) and 27 other tissues See more
Orthologs
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Genomic context

See Map2k1 in Genome Data Viewer
Location:
9 C; 9 34.55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64093066..64160887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64185769..64253605, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene predicted gene, 22455 Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene timeless interacting protein Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Golgi inheritance ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar cortex formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in melanosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of vascular associated smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 1
Names
ERK activator kinase 1
MAP kinase kinase 1
MAPK/ERK kinase 1
protein kinase, mitogen activated, kinase 1, p45
NP_001397403.1
NP_032953.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410474.1NP_001397403.1  dual specificity mitogen-activated protein kinase kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160118
    UniProtKB/TrEMBL
    Q3U3F4, Q3UK05, Q9JJE1
  2. NM_008927.5NP_032953.1  dual specificity mitogen-activated protein kinase kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_032953.1

    Status: VALIDATED

    Source sequence(s)
    AC160118
    Consensus CDS
    CCDS23277.1
    UniProtKB/Swiss-Prot
    P31938
    UniProtKB/TrEMBL
    Q3TMJ8, Q3U3F4, Q3UK05, Q9JJE1
    Related
    ENSMUSP00000005066.9, ENSMUST00000005066.9
    Conserved Domains (1) summary
    cd06650
    Location:62380
    PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64093066..64160887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)