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Map2k1 mitogen-activated protein kinase kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26395, updated on 25-May-2021

Summary

Official Symbol
Map2k1provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 1provided by MGI
Primary source
MGI:MGI:1346866
See related
Ensembl:ENSMUSG00000004936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mek1; Prkm; MEKK1; MAPKK1; Prkmk1
Expression
Ubiquitous expression in frontal lobe adult (RPKM 50.3), cortex adult (RPKM 32.1) and 27 other tissues See more
Orthologs
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Genomic context

See Map2k1 in Genome Data Viewer
Location:
9 C; 9 34.55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64093051..64160887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64185769..64253605, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64033600..64101412, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22455 Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene timeless interacting protein Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Golgi inheritance ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar cortex formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within melanosome transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription elongation from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of vascular associated smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to axon injury ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 1
Names
ERK activator kinase 1
MAP kinase kinase 1
MAPK/ERK kinase 1
protein kinase, mitogen activated, kinase 1, p45
NP_032953.1
XP_006511259.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008927.4NP_032953.1  dual specificity mitogen-activated protein kinase kinase 1

    See identical proteins and their annotated locations for NP_032953.1

    Status: VALIDATED

    Source sequence(s)
    AK165894, BY698931
    Consensus CDS
    CCDS23277.1
    UniProtKB/Swiss-Prot
    P31938
    UniProtKB/TrEMBL
    Q3TMJ8
    Related
    ENSMUSP00000005066.9, ENSMUST00000005066.9
    Conserved Domains (1) summary
    cd06650
    Location:62380
    PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64093051..64160887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511196.5XP_006511259.1  dual specificity mitogen-activated protein kinase kinase 1 isoform X1

    Conserved Domains (1) summary
    cd06650
    Location:40358
    PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1
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