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Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 26385, updated on 5-Aug-2018

Summary

Official Symbol
Grk6provided by MGI
Official Full Name
G protein-coupled receptor kinase 6provided by MGI
Primary source
MGI:MGI:1347078
See related
Ensembl:ENSMUSG00000074886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gprk6
Expression
Ubiquitous expression in spleen adult (RPKM 77.5), thymus adult (RPKM 59.5) and 27 other tissues See more
Orthologs

Genomic context

See Grk6 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55445072..55460927)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55546695..55562288)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor) Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene drebrin 1 Neighboring gene microRNA 6944

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
beta-adrenergic receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
desensitization of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 6
Names
g protein-coupled receptor kinase GRK6
NP_001033107.1
NP_001106182.1
NP_001272992.1
NP_001272993.1
NP_001272994.1
NP_001272995.1
NP_036068.2
XP_006517314.1
XP_006517315.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038018.4NP_001033107.1  G protein-coupled receptor kinase 6 isoform a

    See identical proteins and their annotated locations for NP_001033107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    Consensus CDS
    CCDS49272.1
    UniProtKB/Swiss-Prot
    O70293
    Related
    ENSMUSP00000001115.8, ENSMUST00000001115.15
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001112711.2NP_001106182.1  G protein-coupled receptor kinase 6 isoform c

    See identical proteins and their annotated locations for NP_001106182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    Related
    ENSMUSP00000152968.1, ENSMUST00000224118.1
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001286063.1NP_001272992.1  G protein-coupled receptor kinase 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, Y15799
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YDZ5
    Related
    ENSMUSP00000153623.1, ENSMUST00000224653.1
    Conserved Domains (3) summary
    smart00220
    Location:154416
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:153437
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:3147
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  4. NM_001286064.1NP_001272993.1  G protein-coupled receptor kinase 6 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YDA5
    Related
    ENSMUSP00000153344.1, ENSMUST00000224995.1
    Conserved Domains (3) summary
    smart00220
    Location:186443
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185464
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. NM_001286065.1NP_001272994.1  G protein-coupled receptor kinase 6 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YE10
    Related
    ENSMUSP00000153668.1, ENSMUST00000225925.1
    Conserved Domains (3) summary
    smart00220
    Location:186414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185435
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001286066.1NP_001272995.1  G protein-coupled receptor kinase 6 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, 3' UTR, and 3' coding region, and cause translation initiation from a downstream start codon. The encoded isoform (g) has a shorter N-terminus and a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    CA528447, CD354984, CT009762, Y15797
    UniProtKB/TrEMBL
    Q9EP84
    Conserved Domains (2) summary
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
  7. NM_011938.4NP_036068.2  G protein-coupled receptor kinase 6 isoform b

    See identical proteins and their annotated locations for NP_036068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    CA528447, CD354984, CT009762, Y15797
    Consensus CDS
    CCDS36676.1
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    Q9EP84
    Related
    ENSMUSP00000097081.3, ENSMUST00000099482.4
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    55445072..55460927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517251.3XP_006517314.1  G protein-coupled receptor kinase 6 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:181443
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:180464
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:30174
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_006517252.1XP_006517315.1  G protein-coupled receptor kinase 6 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
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