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Esrrb estrogen related receptor, beta [ Mus musculus (house mouse) ]

Gene ID: 26380, updated on 22-Jan-2023

Summary

Official Symbol
Esrrbprovided by MGI
Official Full Name
estrogen related receptor, betaprovided by MGI
Primary source
MGI:MGI:1346832
See related
Ensembl:ENSMUSG00000021255 AllianceGenome:MGI:1346832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Err2; Errb; Nr3b2; Estrrb
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues See more
Orthologs
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Genomic context

See Esrrb in Genome Data Viewer
Location:
12 D2; 12 40.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86407891..86568402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86361117..86521628)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40481 Neighboring gene G patch domain containing 2 like Neighboring gene predicted gene, 32666 Neighboring gene predicted gene, 40483 Neighboring gene CRISPRi-validated Esrrb enhancer cluster Neighboring gene predicted gene, 53732 Neighboring gene poly(rC) binding protein 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell dedifferentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription involved in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trophectodermal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trophectodermal cellular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
steroid hormone receptor ERR2
Names
ERR-beta
estrogen receptor related 2
estrogen receptor-like 2
nuclear receptor subfamily 3 group B member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159500.1NP_001152972.1  steroid hormone receptor ERR2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK052256, AV496316, BC044858
    Consensus CDS
    CCDS49117.1
    UniProtKB/Swiss-Prot
    Q61539
    UniProtKB/TrEMBL
    A0A8C6H175, E9QKA2, Q80VS1
    Related
    ENSMUSP00000112103.4, ENSMUST00000116402.10
    Conserved Domains (2) summary
    cd06946
    Location:217436
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:103198
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  2. NM_011934.4NP_036064.3  steroid hormone receptor ERR2 isoform 1

    See identical proteins and their annotated locations for NP_036064.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AK032025, AK052256, AV496316, BB642270, BC044858
    Consensus CDS
    CCDS26066.2
    UniProtKB/Swiss-Prot
    Q61539
    UniProtKB/TrEMBL
    A0A8C6H034, G5E8P8, Q80VS1, Q8CCV5
    Related
    ENSMUSP00000105833.3, ENSMUST00000110204.9
    Conserved Domains (2) summary
    cd06946
    Location:233452
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:119214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    86407891..86568402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515881.3XP_006515944.1  steroid hormone receptor ERR2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6H0L6
    Related
    ENSMUSP00000131335.2, ENSMUST00000167891.2
    Conserved Domains (2) summary
    cd06946
    Location:219438
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:105200
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  2. XM_006515883.4XP_006515946.1  steroid hormone receptor ERR2 isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:52271
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:133
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. XM_006515882.3XP_006515945.1  steroid hormone receptor ERR2 isoform X2

    Conserved Domains (2) summary
    cd06946
    Location:112331
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:3393
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers