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Esrra estrogen related receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 26379, updated on 13-May-2025
Official Symbol
Esrraprovided by MGI
Official Full Name
estrogen related receptor, alphaprovided by MGI
Primary source
MGI:MGI:1346831
See related
Ensembl:ENSMUSG00000024955 AllianceGenome:MGI:1346831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Err1; Nr3b1; Estrra; ERRalpha
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in duodenum adult (RPKM 141.5), small intestine adult (RPKM 86.0) and 22 other tissues See more
Orthologs
human all
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See Esrra in Genome Data Viewer
Location:
19 A; 19 5.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6888345..6899182, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6910977..6922048, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54051 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene peroxiredoxin 5 Neighboring gene tRNA methyltransferase 11-2 Neighboring gene microRNA 6990 Neighboring gene STARR-positive B cell enhancer ABC_E780 Neighboring gene cation channel sperm associated auxiliary subunit zeta Neighboring gene potassium channel, subfamily K, member 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, et al. Autophagy, 2018. PMID 28841353, Free PMC Article
  2. Clinical implication of estrogen-related receptor (ERR) expression in uterine endometrial cancers. Fujimoto J, et al. J Steroid Biochem Mol Biol, 2009 Aug. PMID 19416752
  3. Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway. Tremblay AM, et al. Mol Endocrinol, 2010 Jan. PMID 19901197, Free PMC Article
  4. Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells. Likhite N, et al. Mol Cell Biol, 2019 Mar 1. PMID 30602497, Free PMC Article
  5. Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α. Lu Y, et al. Eur J Pharmacol, 2019 Jan 15. PMID 30342030

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression.
    Title: Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression.
  2. ERRalpha fosters running endurance by driving myofiber aerobic transformation and fuel efficiency.
    Title: ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency.
  3. Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1alpha-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells.
    Title: Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.
  4. Estrogen-related Receptor Alpha (ERRalpha) is Required for PGC-1alpha-dependent Gene Expression in the Mouse Brain.
    Title: Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain.
  5. The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
    Title: The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
  6. Estrogen-related receptor alpha (ERRalpha) is a key regulator of intestinal homeostasis and protects against colitis.
    Title: Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.
  7. Inhibition of Estrogen-Related Receptor alpha Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis.
    Title: Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis.
  8. Down-regulation of estrogen-related receptor alpha (ERRalpha) inhibits gastric cancer cell migration and invasion in vitro and in vivo.
    Title: Down-regulation of estrogen-related receptor alpha (ERRα) inhibits gastric cancer cell migration and invasion in vitro and in vivo.
  9. Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
    Title: Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
  10. A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
    Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
steroid hormone receptor ERR1
Names
ERR-alpha
Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
estrogen receptor related 1
estrogen receptor-like 1
nuclear receptor subfamily 3 group B member 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413228.1 → NP_001400157.1  steroid hormone receptor ERR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120557

  2. NM_001413229.1 → NP_001400158.1  steroid hormone receptor ERR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120557

  3. NM_007953.3 → NP_031979.2  steroid hormone receptor ERR1 isoform 1

    See identical proteins and their annotated locations for NP_031979.2

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Consensus CDS
    CCDS29509.1
    UniProtKB/Swiss-Prot
    B2RRU9, O08580, Q3U110
    UniProtKB/TrEMBL
    G3UY24
    Related
    ENSMUSP00000025906.4, ENSMUST00000025906.12
    Conserved Domains (2) summary
    cd06946
    Location:196 → 419
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:73 → 168
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6888345..6899182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08580.4 GenPept UniProtKB/Swiss-Prot:O08580

Gene LinkOut

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