Esrra estrogen related receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esrraprovided by MGI
Official Full Name: estrogen related receptor, alphaprovided by MGI
Primary source: MGI:MGI:1346831
See related: Ensembl:ENSMUSG00000024955 AllianceGenome:MGI:1346831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Err1; Nr3b1; Estrra; ERRalpha
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 141.5), small intestine adult (RPKM 86.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.08 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6888345..6899416, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6910977..6922048, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1alpha-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells.
Title: Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.
Estrogen-related Receptor Alpha (ERRalpha) is Required for PGC-1alpha-dependent Gene Expression in the Mouse Brain.
Title: Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain.
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
Title: The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
Estrogen-related receptor alpha (ERRalpha) is a key regulator of intestinal homeostasis and protects against colitis.
Title: Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.
Inhibition of Estrogen-Related Receptor alpha Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis.
Title: Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis.
Down-regulation of estrogen-related receptor alpha (ERRalpha) inhibits gastric cancer cell migration and invasion in vitro and in vivo.
Title: Down-regulation of estrogen-related receptor alpha (ERRα) inhibits gastric cancer cell migration and invasion in vitro and in vivo.
Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
Title: Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways.
Title: Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
These findings support the therapeutic application of resveratrol and ERR-alpha in combating obesity-mediated cardiac dysfunction.
Title: Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BARC0081 (e-PCR)
- UniSTS:277893

Esrra (e-PCR), detects polymorphism
- UniSTS:496007

Esrra (e-PCR), detects polymorphism
- UniSTS:527344

Homology

Homologs of the Esrra gene: The Esrra gene is conserved in chimpanzee, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 368 organisms have orthologs with human gene Esrra
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: steroid hormone receptor ERR1

Names: ERR-alpha; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1); estrogen receptor related 1; estrogen receptor-like 1; nuclear receptor subfamily 3 group B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413228.1 → NP_001400157.1 steroid hormone receptor ERR1 isoform 2

Status: VALIDATED

Source sequence(s)

AC120557
NM_001413229.1 → NP_001400158.1 steroid hormone receptor ERR1 isoform 2

Status: VALIDATED

Source sequence(s)

AC120557
NM_007953.3 → NP_031979.2 steroid hormone receptor ERR1 isoform 1

See identical proteins and their annotated locations for NP_031979.2

Status: VALIDATED

Source sequence(s)

AC120557

Consensus CDS

CCDS29509.1

UniProtKB/Swiss-Prot

O08580, Q3U110

UniProtKB/TrEMBL

A0A6P5P046

Related

ENSMUSP00000025906.4, ENSMUST00000025906.12

Conserved Domains (2) summary

cd06946
Location:196 → 419

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:73 → 168

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6888345..6899416 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527111.3 → XP_006527174.1 steroid hormone receptor ERR1 isoform X1

Conserved Domains (2) summary

cd06946
Location:225 → 448

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:137 → 197

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_030250950.2 → XP_030106810.1 steroid hormone receptor ERR1 isoform X2

Conserved Domains (2) summary

cd06946
Location:53 → 276

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 25

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_017318209.3 → XP_017173698.1 steroid hormone receptor ERR1 isoform X2

Conserved Domains (2) summary

cd06946
Location:53 → 276

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 25

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers