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Esrra estrogen related receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 26379, updated on 9-Mar-2023

Summary

Official Symbol
Esrraprovided by MGI
Official Full Name
estrogen related receptor, alphaprovided by MGI
Primary source
MGI:MGI:1346831
See related
Ensembl:ENSMUSG00000024955 AllianceGenome:MGI:1346831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Err1; Nr3b1; Estrra; ERRalpha
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 141.5), small intestine adult (RPKM 86.0) and 22 other tissues See more
Orthologs
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Genomic context

See Esrra in Genome Data Viewer
Location:
19 A; 19 5.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6888345..6899416, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6910977..6922048, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54051 Neighboring gene peroxiredoxin 5 Neighboring gene tRNA methyltransferase 11-2 Neighboring gene microRNA 6990 Neighboring gene cation channel sperm associated auxiliary subunit zeta Neighboring gene potassium channel, subfamily K, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
steroid hormone receptor ERR1
Names
ERR-alpha
Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
estrogen receptor related 1
estrogen receptor-like 1
nuclear receptor subfamily 3 group B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413228.1NP_001400157.1  steroid hormone receptor ERR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120557
  2. NM_001413229.1NP_001400158.1  steroid hormone receptor ERR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120557
  3. NM_007953.3NP_031979.2  steroid hormone receptor ERR1 isoform 1

    See identical proteins and their annotated locations for NP_031979.2

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Consensus CDS
    CCDS29509.1
    UniProtKB/Swiss-Prot
    O08580, Q3U110
    UniProtKB/TrEMBL
    A0A6P5P046
    Related
    ENSMUSP00000025906.4, ENSMUST00000025906.12
    Conserved Domains (2) summary
    cd06946
    Location:196419
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:73168
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6888345..6899416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527111.3XP_006527174.1  steroid hormone receptor ERR1 isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:225448
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:137197
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  2. XM_030250950.2XP_030106810.1  steroid hormone receptor ERR1 isoform X2

    Conserved Domains (2) summary
    cd06946
    Location:53276
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:125
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. XM_017318209.3XP_017173698.1  steroid hormone receptor ERR1 isoform X2

    Conserved Domains (2) summary
    cd06946
    Location:53276
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:125
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers