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Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 26365, updated on 9-Apr-2019

Summary

Official Symbol
Ceacam1provided by MGI
Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:1347245
See related
Ensembl:ENSMUSG00000074272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a
Expression
Biased expression in colon adult (RPKM 419.7), large intestine adult (RPKM 308.1) and 3 other tissues See more

Genomic context

See Ceacam1 in Genome Data Viewer
Location:
7 A3; 7 13.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (25461702..25477625, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26246721..26262644, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene RELT tumor necrosis factor receptor pseudogene Neighboring gene chaperonin containing Tcp1, subunit 4 (delta) pseudogene Neighboring gene predicted gene, 38967 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding ISO
Inferred from Sequence Orthology
more info
 
bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
filamin binding ISO
Inferred from Sequence Orthology
more info
 
granulocyte colony-stimulating factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
virion binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT virion binding IDA
Inferred from Direct Assay
more info
PubMed 
virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
granulocyte colony-stimulating factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
insulin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation by host of viral process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of CD4-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of CD8-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immunoglobulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 1
Names
BGP-1
CEA-related cell adhesion molecule 1
MHV-R
biliary glycoprotein 1
biliary glycoprotein D
carcinoembryonic antigen 1
carcinoembryonic antigen 7
hepatitis virus (MHV-4) susceptibility
hepatitis virus receptor
murine hepatitis virus receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039185.1NP_001034274.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001034274.1

    Status: VALIDATED

    Source sequence(s)
    AAHY01060000, AB236328, M77196
    Consensus CDS
    CCDS20984.1
    UniProtKB/Swiss-Prot
    P31809
    UniProtKB/TrEMBL
    Q3LFS9, Q925P3
    Related
    ENSMUSP00000096266.1, ENSMUST00000098669.7
    Conserved Domains (6) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00408
    Location:340401
    IGc2; Immunoglobulin C-2 Type
    cd12841
    Location:416452
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146235
    Ig; Immunoglobulin domain
  2. NM_001039186.1NP_001034275.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001034275.1

    Status: VALIDATED

    Source sequence(s)
    AAHY01060000, M77196
    Consensus CDS
    CCDS39839.1
    UniProtKB/Swiss-Prot
    P31809
    Related
    ENSMUSP00000096263.2, ENSMUST00000098666.8
    Conserved Domains (6) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00408
    Location:340401
    IGc2; Immunoglobulin C-2 Type
    cd12841
    Location:416452
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146235
    Ig; Immunoglobulin domain
  3. NM_001039187.1NP_001034276.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001034276.1

    Status: VALIDATED

    Source sequence(s)
    AAHY01060000, AB236329
    Consensus CDS
    CCDS85244.1
    UniProtKB/TrEMBL
    Q3LFS8
    Related
    ENSMUSP00000146066.1, ENSMUST00000206687.1
    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd12841
    Location:236272
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    smart00410
    Location:153226
    IG_like; Immunoglobulin like
    cl11960
    Location:142232
    Ig; Immunoglobulin domain
  4. NM_011926.2NP_036056.2  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_036056.2

    Status: VALIDATED

    Source sequence(s)
    AAHY01060000, AB236328
    Consensus CDS
    CCDS20985.1
    UniProtKB/TrEMBL
    Q3LFS9
    Related
    ENSMUSP00000096265.1, ENSMUST00000098668.2
    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00408
    Location:160221
    IGc2; Immunoglobulin C-2 Type
    cd12841
    Location:236272
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    smart00410
    Location:153226
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    25461702..25477625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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