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GNL3 G protein nucleolar 3 [ Homo sapiens (human) ]

Gene ID: 26354, updated on 13-Feb-2019

Summary

Official Symbol
GNL3provided by HGNC
Official Full Name
G protein nucleolar 3provided by HGNC
Primary source
HGNC:HGNC:29931
See related
Ensembl:ENSG00000163938 MIM:608011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS; E2IG3; NNP47; C77032
Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues See more
Orthologs

Genomic context

See GNL3 in Genome Data Viewer
Location:
3p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (52685920..52694497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52719936..52728513)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 856, pseudogene Neighboring gene RNA, U6atac small nuclear 16, pseudogene Neighboring gene polybromo 1 Neighboring gene small nucleolar RNA, C/D box 136 Neighboring gene small nucleolar RNA, C/D box 19B Neighboring gene small nucleolar RNA, C/D box 19C Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene NIMA related kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association of mood-incongruent psychotic bipolar disorder.
NHGRI GWA Catalog
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human guanine nucleotide binding protein-like 3 (GNL3) at amino acid residues 509-510 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular space HDA PubMed 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein-like 3
Names
E2-induced gene 3 protein
estradiol-induced nucleotide binding protein
guanine nucleotide binding protein-like 3 (nucleolar)
novel nucleolar protein 47
nucleolar GTP-binding protein 3
nucleostemin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027871.1 RefSeqGene

    Range
    5001..13578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014366.5NP_055181.3  guanine nucleotide-binding protein-like 3 isoform 1

    See identical proteins and their annotated locations for NP_055181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI028402, AK027514, BC001024, CF272475
    Consensus CDS
    CCDS2861.1
    UniProtKB/Swiss-Prot
    Q9BVP2
    Related
    ENSP00000395772.1, ENST00000418458.5
    Conserved Domains (3) summary
    cd04178
    Location:142307
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:133419
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:1685
    GN3L_Grn1; GNL3L/Grn1 putative GTPase
  2. NM_206825.1NP_996561.1  guanine nucleotide-binding protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_996561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AF191018, AI028402, AK027514
    Consensus CDS
    CCDS43100.1
    UniProtKB/Swiss-Prot
    Q9BVP2
    Related
    ENSP00000378278.2, ENST00000394799.6
    Conserved Domains (3) summary
    cd04178
    Location:130295
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:121407
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:473
    GN3L_Grn1; GNL3L/Grn1 putative GTPase
  3. NM_206826.1NP_996562.1  guanine nucleotide-binding protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_996562.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AF191018, AK027514, BC001024, BF732788
    Consensus CDS
    CCDS43100.1
    UniProtKB/Swiss-Prot
    Q9BVP2
    Conserved Domains (3) summary
    cd04178
    Location:130295
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:121407
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:473
    GN3L_Grn1; GNL3L/Grn1 putative GTPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    52685920..52694497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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