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GBP3 guanylate binding protein 3 [ Homo sapiens (human) ]

Gene ID: 2635, updated on 12-Oct-2019

Summary

Official Symbol
GBP3provided by HGNC
Official Full Name
guanylate binding protein 3provided by HGNC
Primary source
HGNC:HGNC:4184
See related
Ensembl:ENSG00000117226 MIM:600413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]
Expression
Broad expression in duodenum (RPKM 41.6), small intestine (RPKM 35.5) and 23 other tissues See more
Orthologs

Genomic context

See GBP3 in Genome Data Viewer
Location:
1p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89006677..89022870, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89472360..89488556, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 pseudogene Neighboring gene kynurenine aminotransferase 3 Neighboring gene RBMX like 1 Neighboring gene uncharacterized LOC105378841 Neighboring gene guanylate binding protein 1 Neighboring gene prostaglandin E synthase 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10961, DKFZp686E0974, DKFZp686L15228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanylate-binding protein 3
Names
GTP-binding protein 3
guanine nucleotide-binding protein 3
guanylate-binding protein 3 delta C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319179.1NP_001306108.1  guanylate-binding protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK001823, AK309096, AL160008, BC144650, BP281050, CA450307
    Conserved Domains (3) summary
    pfam02841
    Location:203495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:209495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:1201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001319180.1NP_001306109.1  guanylate-binding protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK001823, AK309096, AL160008, BP281050, CA450307
    Conserved Domains (3) summary
    pfam02841
    Location:148440
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:154440
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:10146
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001319181.1NP_001306110.1  guanylate-binding protein 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL160008, BP281050, JF927951
    UniProtKB/Swiss-Prot
    Q9H0R5
    Conserved Domains (3) summary
    pfam02841
    Location:282529
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:288529
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. NM_018284.3NP_060754.2  guanylate-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_060754.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL160008, CR936755, CR936758
    Consensus CDS
    CCDS717.2
    UniProtKB/Swiss-Prot
    Q9H0R5
    Related
    ENSP00000359512.4, ENST00000370481.9
    Conserved Domains (3) summary
    pfam02841
    Location:282574
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:288574
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_135007.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK001823, AK309096, BC063819, BP281050, CA450307
    Related
    ENST00000489444.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89006677..89022870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541234.2XP_011539536.1  guanylate-binding protein 3 isoform X3

    Conserved Domains (3) summary
    pfam02841
    Location:210493
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:210493
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:18209
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006710574.3XP_006710637.1  guanylate-binding protein 3 isoform X1

    Conserved Domains (3) summary
    pfam02841
    Location:282547
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:288547
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_011541233.1XP_011539535.1  guanylate-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011539535.1

    Conserved Domains (3) summary
    pfam02841
    Location:203495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:209495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:1201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_005270743.2XP_005270800.1  guanylate-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005270800.1

    Conserved Domains (3) summary
    pfam02841
    Location:203495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:209495
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:1201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017001013.1XP_016856502.1  guanylate-binding protein 3 isoform X4

    Conserved Domains (3) summary
    pfam02841
    Location:148440
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:154440
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:10146
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017001014.1XP_016856503.1  guanylate-binding protein 3 isoform X5

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