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MYCBP MYC binding protein [ Homo sapiens (human) ]

Gene ID: 26292, updated on 13-Mar-2020

Summary

Official Symbol
MYCBPprovided by HGNC
Official Full Name
MYC binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7554
See related
Ensembl:ENSG00000214114 MIM:606535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMY-1
Summary
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in testis (RPKM 11.1), colon (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See MYCBP in Genome Data Viewer
Location:
1p34.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (38862490..38873378, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39328162..39339050, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1139 Neighboring gene Ras related GTP binding C Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene GJA9-MYCBP readthrough Neighboring gene uncharacterized LOC105378663 Neighboring gene gap junction protein alpha 9 Neighboring gene rhomboid like 2 Neighboring gene uncharacterized LOC105378662

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-Myc-binding protein
Names
associate of myc-1
c-myc binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012333.5NP_036465.2  C-Myc-binding protein

    See identical proteins and their annotated locations for NP_036465.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AL139260, BC008686, BU601195, CN478752
    Consensus CDS
    CCDS431.1
    UniProtKB/Swiss-Prot
    Q99417
    Related
    ENSP00000380702.2, ENST00000397572.5

RNA

  1. NR_037632.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it does not meet quality criteria. As such there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AL139260, BQ437941, BU601195, CN478752

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    38862490..38873378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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