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AK5 adenylate kinase 5 [ Homo sapiens (human) ]

Gene ID: 26289, updated on 25-Oct-2020

Summary

Official Symbol
AK5provided by HGNC
Official Full Name
adenylate kinase 5provided by HGNC
Primary source
HGNC:HGNC:365
See related
Ensembl:ENSG00000154027 MIM:608009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK6
Summary
This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 40.3) and testis (RPKM 0.8) See more
Orthologs

Genomic context

See AK5 in Genome Data Viewer
Location:
1p31.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77281908..77559966)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (77747662..78025654)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class K Neighboring gene alanyl-tRNA synthetase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105378808 Neighboring gene RNA, U7 small nuclear 8 pseudogene Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of adenylate kinase 5 (AK5) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
dADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleotide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine ribonucleotide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenylate kinase isoenzyme 5
Names
AK 5
ATP-AMP transphosphorylase 5
adenylate kinase 6
NP_036225.2
NP_777283.1
XP_005270796.1
XP_006710635.1
XP_016856497.1
XP_016856498.1
XP_016856499.1
XP_016856500.1
XP_016856501.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012093.4NP_036225.2  adenylate kinase isoenzyme 5 isoform 2

    See identical proteins and their annotated locations for NP_036225.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate and longer first exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC093433, AC093575, AC095030, KF459522
    Consensus CDS
    CCDS676.1
    UniProtKB/Swiss-Prot
    Q9Y6K8
    Related
    ENSP00000341430.5, ENST00000344720.9
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  2. NM_174858.3NP_777283.1  adenylate kinase isoenzyme 5 isoform 1

    See identical proteins and their annotated locations for NP_777283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript yet it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF445193, AW665223, BC036666
    Consensus CDS
    CCDS675.1
    UniProtKB/Swiss-Prot
    Q9Y6K8
    Related
    ENSP00000346577.2, ENST00000354567.7
    Conserved Domains (2) summary
    TIGR01360
    Location:374561
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:378550
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    77281908..77559966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001012.1XP_016856501.1  adenylate kinase isoenzyme 5 isoform X4

  2. XM_005270739.5XP_005270796.1  adenylate kinase isoenzyme 5 isoform X1

    See identical proteins and their annotated locations for XP_005270796.1

    Conserved Domains (2) summary
    TIGR01360
    Location:350537
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:354526
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  3. XM_017001010.2XP_016856499.1  adenylate kinase isoenzyme 5 isoform X3

  4. XM_017001009.1XP_016856498.1  adenylate kinase isoenzyme 5 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y6K8
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  5. XM_006710572.3XP_006710635.1  adenylate kinase isoenzyme 5 isoform X2

    See identical proteins and their annotated locations for XP_006710635.1

    UniProtKB/Swiss-Prot
    Q9Y6K8
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  6. XM_017001008.2XP_016856497.1  adenylate kinase isoenzyme 5 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y6K8
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  7. XM_017001011.2XP_016856500.1  adenylate kinase isoenzyme 5 isoform X3

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