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CLDN17 claudin 17 [ Homo sapiens (human) ]

Gene ID: 26285, updated on 23-Nov-2021

Summary

Official Symbol
CLDN17provided by HGNC
Official Full Name
claudin 17provided by HGNC
Primary source
HGNC:HGNC:2038
See related
Ensembl:ENSG00000156282 MIM:617005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]
Orthologs
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Genomic context

See CLDN17 in Genome Data Viewer
Location:
21q21.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (30165565..30166805, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (31537883..31539123, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 1 Neighboring gene GRIK1 antisense RNA 2 Neighboring gene GRIK1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 307 Neighboring gene claudin 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association of lipid-lowering response to statins in combined study populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126552, MGC126554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
claudin-17
Names
human CLDN17 gene for claudin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012131.3NP_036263.1  claudin-17

    See identical proteins and their annotated locations for NP_036263.1

    Status: REVIEWED

    Source sequence(s)
    AP000884, BC101503
    Consensus CDS
    CCDS13586.1
    UniProtKB/Swiss-Prot
    P56750
    Related
    ENSP00000286808.3, ENST00000286808.5
    Conserved Domains (1) summary
    cl21598
    Location:6182
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    30165565..30166805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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