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ERAL1 Era like 12S mitochondrial rRNA chaperone 1 [ Homo sapiens (human) ]

Gene ID: 26284, updated on 24-Nov-2020

Summary

Official Symbol
ERAL1provided by HGNC
Official Full Name
Era like 12S mitochondrial rRNA chaperone 1provided by HGNC
Primary source
HGNC:HGNC:3424
See related
Ensembl:ENSG00000132591 MIM:607435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERA; CEGA; ERA-W; H-ERA; ERAL1A; ERAL1B; HERA-A; HERA-B; PRLTS6
Summary
The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See ERAL1 in Genome Data Viewer
Location:
17q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28855016..28861061)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27182043..27188072)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 4 Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with ERAL1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal small subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
GTPase Era, mitochondrial
Names
ERA-like protein 1
Era G-protein-like 1
GTP-binding protein era homolog
GTPase, human homolog of E. coli essential cell cycle protein Era
conserved ERA-like GTPase
era (E. coli G-protein homolog)-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317985.2NP_001304914.1  GTPase Era, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK023342, BC019094, BM683046, BX384612, DA559976
    UniProtKB/Swiss-Prot
    O75616
    Conserved Domains (3) summary
    cd04163
    Location:112326
    Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
    COG1159
    Location:108436
    Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
    cd00105
    Location:386415
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  2. NM_001317986.2NP_001304915.1  GTPase Era, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC024267, AK023342, BC019094, BI758329, BM683046, DA559976
    UniProtKB/Swiss-Prot
    O75616
    Conserved Domains (3) summary
    cd04163
    Location:112245
    Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
    COG1159
    Location:108354
    Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
    cd00105
    Location:304333
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  3. NM_005702.4NP_005693.1  GTPase Era, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_005693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC019094, BM683046, DA559976
    Consensus CDS
    CCDS11244.1
    UniProtKB/Swiss-Prot
    O75616
    Related
    ENSP00000254928.5, ENST00000254928.10
    Conserved Domains (1) summary
    cl26333
    Location:108437
    FeoB_N; Ferrous iron transport protein B

RNA

  1. NR_134328.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF082658, AK023342, BC019094, BM683046, DA559976
    Related
    ENST00000461894.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28855016..28861061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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