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FBXO3 F-box protein 3 [ Homo sapiens (human) ]

Gene ID: 26273, updated on 4-Nov-2018

Summary

Official Symbol
FBXO3provided by HGNC
Official Full Name
F-box protein 3provided by HGNC
Primary source
HGNC:HGNC:13582
See related
Ensembl:ENSG00000110429 MIM:609089; Vega:OTTHUMG00000166244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBA; FBX3
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See FBXO3 in Genome Data Viewer
Location:
11p13
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (33740944..33774525, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33762490..33796071, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KIAA1549 like Neighboring gene uncharacterized LOC105376617 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene CD59 molecule (CD59 blood group) Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene FBXO3 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with F-box protein 3 (FBXO3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564B092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
F-box only protein 3
Names
F-box protein FBX3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012175.3NP_036307.2  F-box only protein 3 isoform 1

    See identical proteins and their annotated locations for NP_036307.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1) which includes a highly acidic D/E-rich domain and two poly-R pieces at the C-terminus.
    Source sequence(s)
    BC039291, BC046110
    Consensus CDS
    CCDS7887.1
    UniProtKB/Swiss-Prot
    Q9UK99
    UniProtKB/TrEMBL
    Q49AF1
    Related
    ENSP00000265651.3, OTTHUMP00000232318, ENST00000265651.7, OTTHUMT00000388665
    Conserved Domains (3) summary
    smart00860
    Location:121249
    SMI1_KNR4; SMI1 / KNR4 family
    pfam12937
    Location:1357
    F-box-like; F-box-like
    cl01119
    Location:279404
    DUF525; ApaG domain
  2. NM_033406.2NP_208385.1  F-box only protein 3 isoform 2

    See identical proteins and their annotated locations for NP_208385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is divergent from variant 1 at the 3' terminus. It encodes a C-terminal truncated isoform, which lacks the D/E-rich domain and poly-Rs, as compared to isoform 1.
    Source sequence(s)
    AF176702, BC017107, BC039291
    Consensus CDS
    CCDS44566.1
    UniProtKB/Swiss-Prot
    Q9UK99
    UniProtKB/TrEMBL
    Q49AF1
    Related
    ENSP00000408836.2, OTTHUMP00000232323, ENST00000448981.6, OTTHUMT00000388670
    Conserved Domains (3) summary
    smart00860
    Location:121249
    SMI1_KNR4; SMI1 / KNR4 family
    pfam12937
    Location:1357
    F-box-like; F-box-like
    cl01119
    Location:279404
    DUF525; ApaG domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    33740944..33774525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017533.2XP_016873022.1  F-box only protein 3 isoform X4

    Related
    ENSP00000435680.1, OTTHUMP00000232417, ENST00000526785.5
  2. XM_011519980.2XP_011518282.1  F-box only protein 3 isoform X1

    Conserved Domains (3) summary
    pfam04379
    Location:294383
    DUF525; Protein of unknown function (DUF525)
    pfam09346
    Location:121249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:1357
    F-box-like; F-box-like
  3. XM_011519982.1XP_011518284.1  F-box only protein 3 isoform X3

    Conserved Domains (1) summary
    pfam04379
    Location:132221
    DUF525; Protein of unknown function (DUF525)
  4. XM_011519981.3XP_011518283.1  F-box only protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011518283.1

    Related
    ENSP00000431745.1, OTTHUMP00000232321, ENST00000534136.5
    Conserved Domains (3) summary
    pfam09346
    Location:121249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:1357
    F-box-like; F-box-like
    cl01119
    Location:279404
    DUF525; Protein of unknown function (DUF525)
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