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SLC13A4 solute carrier family 13 member 4 [ Homo sapiens (human) ]

Gene ID: 26266, updated on 10-Dec-2019

Summary

Official Symbol
SLC13A4provided by HGNC
Official Full Name
solute carrier family 13 member 4provided by HGNC
Primary source
HGNC:HGNC:15827
See related
Ensembl:ENSG00000164707 MIM:604309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAS2; SUT1; SUT-1
Expression
Biased expression in placenta (RPKM 28.4) and testis (RPKM 3.0) See more
Orthologs

Genomic context

See SLC13A4 in Genome Data Viewer
Location:
7q33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (135681231..135728186, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135365979..135412943, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene 11 Neighboring gene RNA, U6 small nuclear 1154, pseudogene Neighboring gene short transmembrane mitochondrial protein 1 Neighboring gene uncharacterized LOC105375521 Neighboring gene family with sequence similarity 180 member A Neighboring gene uncharacterized LOC105375522

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
citrate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:dicarboxylate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:sulfate symporter activity TAS
Traceable Author Statement
more info
 
succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
citrate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
succinate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 13 member 4
Names
Na(+)/sulfate cotransporter SUT-1
solute carrier family 13 (sodium/sulfate symporter), member 4
solute carrier family 13 (sodium/sulfate symporters), member 4
solute carrier family 13 (sodium/sulphate symporters), member 4
sulphate transporter 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318192.2NP_001305121.1  solute carrier family 13 member 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB208809, AC091736, AF169301, BC030689
    UniProtKB/Swiss-Prot
    Q9UKG4
    UniProtKB/TrEMBL
    Q59HF0
    Conserved Domains (2) summary
    cd01115
    Location:38605
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    TIGR00785
    Location:40604
    dass; anion transporter
  2. NM_012450.4NP_036582.2  solute carrier family 13 member 4 isoform 2

    See identical proteins and their annotated locations for NP_036582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB208809, AC091736, AF169301, BC030689
    Consensus CDS
    CCDS5840.1
    UniProtKB/Swiss-Prot
    Q9UKG4
    UniProtKB/TrEMBL
    Q59HF0
    Related
    ENSP00000297282.5, ENST00000354042.8
    Conserved Domains (1) summary
    cd01115
    Location:38604
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    135681231..135728186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516024.3XP_011514326.1  solute carrier family 13 member 4 isoform X1

    See identical proteins and their annotated locations for XP_011514326.1

    Conserved Domains (1) summary
    cl21473
    Location:32570
    ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
  2. XM_017011962.1XP_016867451.1  solute carrier family 13 member 4 isoform X2

  3. XM_017011963.2XP_016867452.1  solute carrier family 13 member 4 isoform X3

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