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FBXO25 F-box protein 25 [ Homo sapiens (human) ]

Gene ID: 26260, updated on 25-Nov-2025
Official Symbol
FBXO25provided by HGNC
Official Full Name
F-box protein 25provided by HGNC
Primary source
HGNC:HGNC:13596
See related
Ensembl:ENSG00000147364 MIM:609098; AllianceGenome:HGNC:13596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX25
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 13.0), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs
mouse all
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See FBXO25 in Genome Data Viewer
Location:
8p23.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (406958..477967)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (204109..275198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (356958..427967)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:299727-300260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:328556-329056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene family with sequence similarity 87 member A Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene testis development related protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene glutamate rich 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. FBXO25 promotes cell proliferation, invasion, and migration of NSCLC. Jiang GY, et al. Tumour Biol, 2016 Oct. PMID 27596142
  2. ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25. Quintero-Barceinas RS, et al. J Biol Chem, 2021 Jan-Jun. PMID 33428929, Free PMC Article
  3. HTLV-1 viral oncoprotein HBZ contributes to the enhancement of HAX-1 stability by impairing the ubiquitination pathway. Tanaka Y, et al. J Cell Physiol, 2021 Apr. PMID 32893878
  4. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. Harich B, et al. J Child Psychol Psychiatry, 2020 May. PMID 31849056, Free PMC Article
  5. A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors. Jang JW, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21596019

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.
    Title: From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.
  2. ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.
    Title: ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.
  3. FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1.
    Title: FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1.
  4. LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis.
    Title: LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis.
  5. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
    Title: FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation.
  6. High FBXO25 expression is associated with non-small-cell lung cancer.
    Title: FBXO25 promotes cell proliferation, invasion, and migration of NSCLC.
  7. FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma.
    Title: Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
  8. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens
    Title: The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.
  9. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
    Title: A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
  10. Beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments.
    Title: Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC20256, MGC51975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SCF ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
F-box only protein 25
Names
F-box protein Fbx25

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012173.4 → NP_036305.2  F-box only protein 25 isoform 3

    See identical proteins and their annotated locations for NP_036305.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal exons, as compared to variant 1. The encoded isoform (3) has an alternate N-terminus and lacks an internal segment in the 3' region, as compared to isoform 1.
    Source sequence(s)
    AA316216, AC083964, AF419858, AI223050, BC012143, BC050393
    Consensus CDS
    CCDS5954.1
    UniProtKB/Swiss-Prot
    Q8TCJ0
    Related
    ENSP00000341345.2, ENST00000352684.2

  2. NM_183420.2 → NP_904356.1  F-box only protein 25 isoform 2

    See identical proteins and their annotated locations for NP_904356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform (2) is missing an internal segment, as compared to isoform 1.
    Source sequence(s)
    AA316216, AC083964, AF419858, AI223050, BC050393
    Consensus CDS
    CCDS5952.1
    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000342077.4, ENST00000350302.8

  3. NM_183421.2 → NP_904357.1  F-box only protein 25 isoform 1

    See identical proteins and their annotated locations for NP_904357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA316216, AC083964, AF419858, AI223050, BC050393
    Consensus CDS
    CCDS5953.1
    UniProtKB/Swiss-Prot
    Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000372274.2, ENST00000382824.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    406958..477967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421684.1 → XP_047277640.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000578046.1, ENST00000907987.1

  2. XM_017013314.2 → XP_016868803.1  F-box only protein 25 isoform X3

    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000626472.1, ENST00000956413.1

  3. XM_024447125.2 → XP_024302893.1  F-box only protein 25 isoform X4

    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000578044.1, ENST00000907985.1

  4. XM_017013313.3 → XP_016868802.1  F-box only protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000626475.1, ENST00000956416.1

  5. XM_011534748.4 → XP_011533050.1  F-box only protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011533050.1

    UniProtKB/Swiss-Prot
    Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000626477.1, ENST00000956418.1

  6. XM_024447123.2 → XP_024302891.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3
    Related
    ENSP00000582254.1, ENST00000912195.1

  7. XM_047421683.1 → XP_047277639.1  F-box only protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
    UniProtKB/TrEMBL
    B4DYA3

  8. XM_024447124.2 → XP_024302892.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3

  9. XM_047421685.1 → XP_047277641.1  F-box only protein 25 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    204109..275198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360277.1 → XP_054216252.1  F-box only protein 25 isoform X4

    UniProtKB/TrEMBL
    B4DYA3

  2. XM_054360275.1 → XP_054216250.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3

  3. XM_054360274.1 → XP_054216249.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3

  4. XM_054360276.1 → XP_054216251.1  F-box only protein 25 isoform X2

    UniProtKB/TrEMBL
    B4DYA3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCJ0.3 GenPept UniProtKB/Swiss-Prot:Q8TCJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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