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FBXO25 F-box protein 25 [ Homo sapiens (human) ]

Gene ID: 26260, updated on 9-Feb-2020

Summary

Official Symbol
FBXO25provided by HGNC
Official Full Name
F-box protein 25provided by HGNC
Primary source
HGNC:HGNC:13596
See related
Ensembl:ENSG00000147364 MIM:609098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX25
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 13.0), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See FBXO25 in Genome Data Viewer
Location:
8p23.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (406808..477967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (356808..419876)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377773 Neighboring gene family with sequence similarity 87 member A Neighboring gene testis development related protein Neighboring gene glutamate rich 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20256, MGC51975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box only protein 25
Names
F-box protein Fbx25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012173.3NP_036305.2  F-box only protein 25 isoform 3

    See identical proteins and their annotated locations for NP_036305.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal exons, as compared to variant 1. The encoded isoform (3) has an alternate N-terminus and lacks an internal segment in the 3' region, as compared to isoform 1.
    Source sequence(s)
    AA316216, AF419858, AI223050, BC012143, BC050393
    Consensus CDS
    CCDS5954.1
    UniProtKB/Swiss-Prot
    Q8TCJ0
    Related
    ENSP00000341345.2, ENST00000352684.2
  2. NM_183420.2NP_904356.1  F-box only protein 25 isoform 2

    See identical proteins and their annotated locations for NP_904356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform (2) is missing an internal segment, as compared to isoform 1.
    Source sequence(s)
    AA316216, AC083964, AF419858, AI223050, BC050393
    Consensus CDS
    CCDS5952.1
    UniProtKB/Swiss-Prot
    Q8TCJ0
    UniProtKB/TrEMBL
    A0A024QZ88
    Related
    ENSP00000342077.3, ENST00000350302.7
  3. NM_183421.2NP_904357.1  F-box only protein 25 isoform 1

    See identical proteins and their annotated locations for NP_904357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA316216, AC083964, AF419858, AI223050, BC050393
    Consensus CDS
    CCDS5953.1
    UniProtKB/Swiss-Prot
    Q8TCJ0
    Related
    ENSP00000372274.2, ENST00000382824.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    406808..477967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013314.1XP_016868803.1  F-box only protein 25 isoform X3

  2. XM_024447125.1XP_024302893.1  F-box only protein 25 isoform X4

  3. XM_017013313.2XP_016868802.1  F-box only protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q8TCJ0
  4. XM_011534748.3XP_011533050.1  F-box only protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011533050.1

    UniProtKB/Swiss-Prot
    Q8TCJ0
  5. XM_024447123.1XP_024302891.1  F-box only protein 25 isoform X2

  6. XM_024447126.1XP_024302894.1  F-box only protein 25 isoform X4

  7. XM_011534749.1XP_011533051.1  F-box only protein 25 isoform X5

    See identical proteins and their annotated locations for XP_011533051.1

  8. XM_024447124.1XP_024302892.1  F-box only protein 25 isoform X2

RNA

  1. XR_002956627.1 RNA Sequence

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