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CABYR calcium binding tyrosine phosphorylation regulated [ Homo sapiens (human) ]

Gene ID: 26256, updated on 5-Aug-2018

Summary

Official Symbol
CABYRprovided by HGNC
Official Full Name
calcium binding tyrosine phosphorylation regulatedprovided by HGNC
Primary source
HGNC:HGNC:15569
See related
Ensembl:ENSG00000154040 MIM:612135; Vega:OTTHUMG00000037365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT88; FSP2; CBP86; FSP-2; CABYRa; CABYRc; CABYRe; CABYRc/d
Summary
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward testis (RPKM 117.5) See more
Orthologs

Genomic context

See CABYR in Genome Data Viewer
Location:
18q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (24138956..24161600)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21718920..21741564)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene uncharacterized LOC112268213 Neighboring gene RNA, U5A small nuclear 6, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 452 Neighboring gene oxysterol binding protein like 1A Neighboring gene RNA, U6 small nuclear 435, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
epithelial cilium movement NAS
Non-traceable Author Statement
more info
PubMed 
sperm capacitation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
sperm end piece IEA
Inferred from Electronic Annotation
more info
 
sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
sperm principal piece IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-binding tyrosine phosphorylation-regulated protein
Names
calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
calcium-binding protein 86
cancer/testis antigen 88
fibrousheathin II
fibrousheathin-2
testis tissue sperm-binding protein Li 84P
testis-specific calcium-binding protein CBP86

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308231.1NP_001295160.1  calcium-binding tyrosine phosphorylation-regulated protein isoform f

    See identical proteins and their annotated locations for NP_001295160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two lacks two alternate exons in the 5' coding region, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC090772, AK225858, AK301889, DB055487
    Consensus CDS
    CCDS77166.1
    UniProtKB/TrEMBL
    A0A0D9SFQ2, B4DXA8
    Related
    ENSP00000486801.1, OTTHUMP00000278345, ENST00000627314.1, OTTHUMT00000480288
  2. NM_012189.3NP_036321.2  calcium-binding tyrosine phosphorylation-regulated protein isoform a

    See identical proteins and their annotated locations for NP_036321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein isoform (a).
    Source sequence(s)
    AF088868, AK225858, AK313243, BC011996, DB055487
    Consensus CDS
    CCDS11881.1
    UniProtKB/Swiss-Prot
    O75952
    UniProtKB/TrEMBL
    A0A024RC21
    Related
    ENSP00000483621.1, OTTHUMP00000162776, ENST00000621648.4, OTTHUMT00000254898
    Conserved Domains (2) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    cl26247
    Location:214414
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. NM_138643.2NP_619584.1  calcium-binding tyrosine phosphorylation-regulated protein isoform d

    See identical proteins and their annotated locations for NP_619584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two internal exons in the 5' region, which results in a downstream translation start codon, and has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The resulting isoform (d) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF295038, AK225858, BC011996, DB055487
    Consensus CDS
    CCDS11883.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000317095.6, OTTHUMP00000162778, ENST00000327201.10, OTTHUMT00000254900
  4. NM_138644.2NP_619585.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

    See identical proteins and their annotated locations for NP_619585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon and an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3 and 7 encode the same isoform c.
    Source sequence(s)
    AF295037, AK225858, BC011996, HY051562
    Consensus CDS
    CCDS42420.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000382421.1, OTTHUMP00000261312, ENST00000399499.5, OTTHUMT00000446181
    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  5. NM_153768.2NP_722452.1  calcium-binding tyrosine phosphorylation-regulated protein isoform b

    See identical proteins and their annotated locations for NP_722452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) lacks an internal segment in the N-terminal region, compared to isoform a.
    Source sequence(s)
    AF329634, AK225858, AK313243, BC011996, DB055487
    Consensus CDS
    CCDS11882.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000382404.3, OTTHUMP00000162777, ENST00000399481.6, OTTHUMT00000254899
    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  6. NM_153769.2NP_722453.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

    See identical proteins and their annotated locations for NP_722453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a. Variants 3 and 7 encode the same isoform c.
    Source sequence(s)
    AK225858, BC011996, DB055487
    Consensus CDS
    CCDS42420.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000382419.3, OTTHUMP00000035470, ENST00000399496.7, OTTHUMT00000090926
    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  7. NM_153770.2NP_722454.1  calcium-binding tyrosine phosphorylation-regulated protein isoform e

    See identical proteins and their annotated locations for NP_722454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a alternate splice junction in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF295039, BC011996, DB055487
    Consensus CDS
    CCDS45840.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000399973.2, OTTHUMP00000261311, ENST00000415309.6, OTTHUMT00000446180
    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    24138956..24161600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451163.1XP_024306931.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

  2. XM_024451159.1XP_024306927.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

    Related
    ENSP00000432870.1, ENST00000463087.5
    Conserved Domains (2) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    cl26247
    Location:214414
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. XM_024451161.1XP_024306929.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  4. XM_024451162.1XP_024306930.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

  5. XM_005258247.2XP_005258304.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X4

    Conserved Domains (1) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  6. XM_024451160.1XP_024306928.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

    Conserved Domains (2) summary
    cd12100
    Location:1048
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    cl26247
    Location:214414
    DNA_pol3_delta2; DNA polymerase III, delta subunit
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