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KCNG2 potassium voltage-gated channel modifier subfamily G member 2 [ Homo sapiens (human) ]

Gene ID: 26251, updated on 2-Oct-2018

Summary

Official Symbol
KCNG2provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily G member 2provided by HGNC
Primary source
HGNC:HGNC:6249
See related
Ensembl:ENSG00000178342 MIM:605696; Vega:OTTHUMG00000044541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCNF2; KV6.2
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KCNG2 in Genome Data Viewer
Location:
18q23
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (79797963..79903512)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77623668..77659816)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284241 Neighboring gene uncharacterized LOC105376875 Neighboring gene CTD phosphatase subunit 1 Neighboring gene PQ loop repeat containing 1 Neighboring gene heat shock factor binding protein 1 like 1 Neighboring gene thioredoxin like 4A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
NHGRI GWA Catalog

Pathways from BioSystems

  • Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystem (from REACTOME)
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystemGlucagon-like Peptide-1 (GLP-1) is secreted by L-cells in the intestine in response to glucose and fatty acids. GLP-1 circulates to the beta cells of the pancreas where it binds a G-protein coupled r...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily G member 2
Names
cardiac potassium channel subunit
potassium channel, voltage gated modifier subfamily G, member 2
potassium voltage-gated channel, subfamily G, member 2
voltage-gated potassium channel subunit Kv6.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012283.1NP_036415.1  potassium voltage-gated channel subfamily G member 2

    See identical proteins and their annotated locations for NP_036415.1

    Status: REVIEWED

    Source sequence(s)
    AJ011021
    Consensus CDS
    CCDS12019.1
    UniProtKB/Swiss-Prot
    Q9UJ96
    Related
    ENSP00000315654.3, OTTHUMP00000041994, ENST00000316249.3, OTTHUMT00000103906
    Conserved Domains (4) summary
    smart00225
    Location:19112
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:218416
    Ion_trans; Ion transport protein
    pfam07885
    Location:359410
    Ion_trans_2; Ion channel
    cl02518
    Location:19112
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    79797963..79903512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525920.3XP_011524222.1  potassium voltage-gated channel subfamily G member 2 isoform X2

    See identical proteins and their annotated locations for XP_011524222.1

    UniProtKB/Swiss-Prot
    Q9UJ96
    Conserved Domains (4) summary
    smart00225
    Location:19112
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:218416
    Ion_trans; Ion transport protein
    pfam07885
    Location:359410
    Ion_trans_2; Ion channel
    cl02518
    Location:19112
    BTB; BTB/POZ domain
  2. XM_011525918.3XP_011524220.1  potassium voltage-gated channel subfamily G member 2 isoform X2

    See identical proteins and their annotated locations for XP_011524220.1

    UniProtKB/Swiss-Prot
    Q9UJ96
    Conserved Domains (4) summary
    smart00225
    Location:19112
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:218416
    Ion_trans; Ion transport protein
    pfam07885
    Location:359410
    Ion_trans_2; Ion channel
    cl02518
    Location:19112
    BTB; BTB/POZ domain
  3. XM_017025705.2XP_016881194.1  potassium voltage-gated channel subfamily G member 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UJ96
    Conserved Domains (4) summary
    smart00225
    Location:19112
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:218416
    Ion_trans; Ion transport protein
    pfam07885
    Location:359410
    Ion_trans_2; Ion channel
    cl02518
    Location:19112
    BTB; BTB/POZ domain
  4. XM_017025704.2XP_016881193.1  potassium voltage-gated channel subfamily G member 2 isoform X1

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