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LCE2B late cornified envelope 2B [ Homo sapiens (human) ]

Gene ID: 26239, updated on 21-Dec-2019

Summary

Official Symbol
LCE2Bprovided by HGNC
Official Full Name
late cornified envelope 2Bprovided by HGNC
Primary source
HGNC:HGNC:16610
See related
Ensembl:ENSG00000159455 MIM:612610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XP5; LEP10; SPRL1B
Summary
This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 134.0) See more
Orthologs

Genomic context

See LCE2B in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (152686123..152687397)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152658599..152659877)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 2D Neighboring gene late cornified envelope 2C Neighboring gene late cornified envelope 2A Neighboring gene late cornified envelope 4A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
keratinization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
late cornified envelope protein 2B
Names
late envelope protein 10
skin-specific protein Xp5
small proline rich-like (epidermal differentiation complex) 1B
small proline-rich-like epidermal differentiation complex protein 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014357.5NP_055172.1  late cornified envelope protein 2B

    See identical proteins and their annotated locations for NP_055172.1

    Status: REVIEWED

    Source sequence(s)
    AF086289, BG211939
    Consensus CDS
    CCDS1020.1
    UniProtKB/Swiss-Prot
    O14633
    Related
    ENSP00000357769.3, ENST00000368780.4
    Conserved Domains (1) summary
    pfam14672
    Location:34109
    LCE; Late cornified envelope

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    152686123..152687397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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