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FBXL5 F-box and leucine rich repeat protein 5 [ Homo sapiens (human) ]

Gene ID: 26234, updated on 8-Jul-2021

Summary

Official Symbol
FBXL5provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 5provided by HGNC
Primary source
HGNC:HGNC:13602
See related
Ensembl:ENSG00000118564 MIM:605655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBL4; FBL5; FLR1
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in kidney (RPKM 49.5), fat (RPKM 39.0) and 25 other tissues See more
Orthologs
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Genomic context

See FBXL5 in Genome Data Viewer
Location:
4p15.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (15604381..15681544, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15606004..15656980, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986185 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene family with sequence similarity 200 member B Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene prefoldin subunit 1 pseudogene Neighboring gene ribosomal protein L10a pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box/LRR-repeat protein 5
Names
F-box protein FBL4/FBL5
p45SKP2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047143.1 RefSeqGene

    Range
    9561..60537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193534.2NP_001180463.1  F-box/LRR-repeat protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001180463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC116651, AF142481, AF199420, AI858616, BC030656, BF432189
    UniProtKB/Swiss-Prot
    Q9UKA1
    Conserved Domains (4) summary
    cd09293
    Location:353407
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:331356
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:204248
    F-box-like; F-box-like
  2. NM_001193535.2NP_001180464.1  F-box/LRR-repeat protein 5 isoform 4

    See identical proteins and their annotated locations for NP_001180464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC116651, AI858616, BF432189, BX537957
    Consensus CDS
    CCDS54745.1
    UniProtKB/Swiss-Prot
    Q9UKA1
    Related
    ENSP00000408679.2, ENST00000412094.6
    Conserved Domains (4) summary
    cd09293
    Location:337391
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7143
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:315340
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:188232
    F-box-like; F-box-like
  3. NM_012161.4NP_036293.1  F-box/LRR-repeat protein 5 isoform 1

    See identical proteins and their annotated locations for NP_036293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC116651, AF142481, AI858616, BC030656, BF432189
    Consensus CDS
    CCDS3415.1
    UniProtKB/Swiss-Prot
    Q9UKA1
    Related
    ENSP00000344866.3, ENST00000341285.8
    Conserved Domains (4) summary
    cd09293
    Location:354408
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:332357
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like; F-box-like

RNA

  1. NR_036464.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC116651, AI858616, BC012320, BC030656, BF432189
    Related
    ENST00000511441.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    15604381..15681544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008019.2XP_016863508.1  F-box/LRR-repeat protein 5 isoform X3

    Conserved Domains (4) summary
    cd09293
    Location:299353
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:1105
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:277302
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:150194
    F-box-like; F-box-like
  2. XM_006713959.3XP_006714022.1  F-box/LRR-repeat protein 5 isoform X1

    Conserved Domains (4) summary
    cd09293
    Location:335389
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:10141
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:313338
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:186230
    F-box-like; F-box-like
  3. XM_011513832.2XP_011512134.1  F-box/LRR-repeat protein 5 isoform X3

    Related
    ENSP00000425472.1, ENST00000513163.5
    Conserved Domains (4) summary
    cd09293
    Location:299353
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:1105
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:277302
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:150194
    F-box-like; F-box-like
  4. XM_011513831.2XP_011512133.1  F-box/LRR-repeat protein 5 isoform X2

    Conserved Domains (4) summary
    cd09293
    Location:318372
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:9124
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:296321
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:169213
    F-box-like; F-box-like
  5. XM_011513833.2XP_011512135.1  F-box/LRR-repeat protein 5 isoform X4

    Conserved Domains (4) summary
    cd09293
    Location:282336
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:260285
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:133177
    F-box-like; F-box-like
    cl15774
    Location:2088
    Hemerythrin-like; Hemerythrin family
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